NCT06307704Completed
Lung US for PEEP Optimization in Robotic Radical Prostatectomy or Cystectomy Patients
Intraoperative Bedside Lung-ultrasound Use to Optimize Positive End-expiratory Pressure for Elective Robotic-assisted Radical Prostatectomy or Cystectomy Patients: a Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 20 Oct 2026
Brief summary (registry, in English)
There is an increasing trend in the use of robotic-assisted radical prostatectomy or cystectomy (RARPC). Preventing lung atelectasis without inducing overdistention of the lung is challenging. Many studies tried to optimize PEEP titration by using methods such as dead space fraction guided and static pulmonary compliance directed techniques, or by using electrical impedance tomography. However, the use of these methods is limited by inaccuracy and the need for sophisticated devices. Bedside Lung ultrasound is fast, easy and economic technique that is gaining interest in the operating room. Ultrasound-guided PEEP titration has been used in bariatric surgeries (different position and usually shorter procedure time) and proved effective in improving oxygenation, compliance and reducing the incidence of postoperative pulmonary atelectasis and hypoxia without causing hemodynamic instability. The aim of this study is to evaluate the effectiveness of intraoperative individualized lung ultrasound-guided stepwise PEEP optimization in patients undergoing RARPC on oxygenation, intraoperative and early postoperative pulmonary complications.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 88 (actual)
- First submitted
- 6 Mar 2024
- Start date
- 1 Apr 2024
- Primary completion date
- 1 Apr 2026
- Lead sponsor
- Nazmy Edward Seif
- Diseases
- Prostate cancer, Bladder cancer
- NCT number
- NCT06307704
What you commit to
- Study type: Interventional
- Participants enrolled: 88
- From 1 Apr 2024 to the primary completion date, 1 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous lung surgery.
- Patients who received invasive mechanical ventilation within the last 30 days before surgery.
Other illness
- Moderate to severe obstructive pulmonary disease (FEV1 \< 80% of predicted).
- Moderate to severe restrictive pulmonary disease (TLC \< 70% of predicted).
- Severe pulmonary hypertension (mean PAP\>55).
- Decompensated cardiac disease (NYHA 3 or 4).
Other
- BMI more than 40.
Who the study is looking for
- ASA I, II \& III.
- Normal respiratory functions or mild lung disease.
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cairo University Hospitals Coordinator of this site? Confirm its status | Cairo | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.