NCT06312748RecruitingPhase 1
Novel Approaches for Improving Vascular Function in Veterans With HFpEF
Source: ClinicalTrials.gov · Last updated 23 Apr 2026
Brief summary (registry, in English)
This project will evaluate the impact of L-Citrulline, tetrahydrobiopterin (BH4), and atorvastatin administration on physical capacity and vascular function in Veterans with heart failure with preserved ejection fraction (HFpEF).
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 90 (estimated)
- First submitted
- 8 Mar 2024
- Start date
- 19 May 2021
- Primary completion date
- 30 Sept 2028
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Heart failure
- NCT number
- NCT06312748
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 90
- From 19 May 2021 to the primary completion date, 30 Sept 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior EF \<50%.
- Patients currently treated with antioxidants, nitrates, PDE-5 inhibitors, or statins.
Other illness
- History of hypersensitivity or allergy to any lipophilic statin.
- Patients with HFpEF secondary to significant uncorrected primary valvular disease.
Lab values
- Active liver disease or unexplained persistent elevations in serum transaminase.
Other
- NYHA Class IV.
- Women who are pregnant or may become pregnant.
Who the study is looking for
- Age 18 years or older and able to give written informed consent.
- New York Heart Association (NYHA) functional class I, II, or III.
- Left Ventricular Ejection Fraction (LVEF) \> 50%.
- Plasma Brain Natriuretic Peptide (BNP) equal to or greater than 150 pg/mL or NT-proBNP equal to or greater than 600 pg/mL at Visit 1, or a BNP equal to or great than 100 pg/mL (or NT-proBNP equal to or greater than 400 pg/mL) and a hospitalization for heart failure within the last 12 months.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| VA Salt Lake City Health Care System, Salt Lake City, UT Coordinator of this site? Confirm its status | Salt Lake City | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.