NCT06316271Not yet recruiting
Endothelial Function in Prehypertension
Endothelial Dysfunction and Cardiovascular Remodeling in Pathophyisiology of Prehypertension
Source: ClinicalTrials.gov · Last updated 18 Mar 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
In the frame of this proposal investigators will test the hypothesis that high normal blood pressure (prehypertension; PreHT) induces systemic endothelial dysfunction and endothelial activation in both micro- and macrocirculation, reduces re-endothelialization potential of human endothelial progenitor cells (EPCs) and increases the level of endothelial extracellular vesicles (EVs), which are accompanied by increased oxidative stress level. Furthermore, initial vascular and left ventricle (LV) remodeling contributes to changes in systemic hemodynamics and may be influenced by altered regulatory role of renin-angiotensin system (RAS) and autonomic nervous system (ANS) in PreHT but otherwise healthy individuals. To distinguish high normal blood pressure effect from those considered normal or high, study will be performed in three groups of individuals: prehypertensive (BP 130-139/85-89 mmHg), hypertensive (stage I, BP 140-150/90-100 mmHg), and controls (BP less than or equal to 129/85 mmHg). Altogether, the impairment of normal vascular relaxation mechanisms, endothelial activation as well as vascular and LV remodeling could play crucial role in increased cardiovascular risk and CVDs incidence in PreHT individuals. Moreover, the prognostic significance of assessing endotehlial dysfunction in hypertension (as well as in PreHT) is yet to be established.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 90 (estimated)
- First submitted
- 2 Mar 2024
- Start date
- 1 Apr 2024
- Primary completion date
- 31 Dec 2024
- Lead sponsor
- Josip Juraj Strossmayer University of Osijek
- Diseases
- High blood pressure
- NCT number
- NCT06316271
What you commit to
- Study type: Observational
- Planned participants: 90
- From 1 Apr 2024 to the primary completion date, 31 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- taking oral contraceptives or any drugs that could affect the endothelium
Other illness
- cardiovascular diseases, but grade I hypertension (BP 140-150/90-100 mmHg)
- diabetes
- kidney disease
- cerebrovascular diseases
- peripheral artery disease
Who the study is looking for
- adults of both sexes with normotensive, prehypertensive and grade I hypertension blood pressure values
Age in the registry: 18 years to 69 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculty of Medicine Osijek Coordinator of this site? Confirm its status | Osijek | Croatia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.