NCT06325280Recruiting
Exercise MRI to Evaluate Cardiorespiratory Fitness in Children With Heart Disease
Utilizing Exercise Cardiovascular and Skeletal Magnetic Resonance Imaging to Evaluate Factors Associated With Cardiorespiratory Fitness in Children With Acquired and Congenital Heart Disease
Source: ClinicalTrials.gov · Last updated 16 Mar 2026
Brief summary (registry, in English)
There are many barriers to heart-healthy lifestyles in pediatric patients with acquired and congenital heart disease. Investigators want to further understand how participants heart and skeletal muscles work together during exercise and evaluate the impact on cardiac function. To do this, the investigators will use magnetic resonance imaging (MRI) to scan the heart and skeletal muscles during exercises to assess blood flow, oxygenation and function.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 20 (estimated)
- First submitted
- 5 Mar 2024
- Start date
- Jan 2025
- Primary completion date
- Dec 2026
- Lead sponsor
- University of Alberta
- NCT number
- NCT06325280
What you commit to
- Study type: Observational
- Planned participants: 20
- From Jan 2025 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Clinical antibody- or cellular-mediated rejection within 3-months of the assessment or during the study period (for HTRs)
- Previous involvement in a CR or exercise intervention program
- Previous exercise stress test demonstrating sustained arrhythmias, ST segment elevation or depression greater than 3mm, an inappropriate rise in blood pressure (BP) (\<20 mmHg) or a systolic BP \>200 mmHg, or symptoms of chest pain or syncope
Other illness
- History of chest pain on exertion; unrepaired/unpalliated CHD
- Arrhythmias in the last year (including supraventricular tachycardia, ventricular tachycardia, atrioventricular block or history of (Mobitz II or worse))
- New York Heart Association class II or worse symptoms
- Active medical inter-current illness limiting ability to participate
- Cognitive impairment limiting the communication needed for the exercise MRI
Other
- Non-English speaking
- Exercise restricted by the patient's clinical cardiologist
- Resting arterial saturation \<85% or oxygen requirements
- Moderate ventricular systolic dysfunction (or worse) at the most recent echocardiogram
- Research MRI contraindications (e.g. any type of pacemaker), or any orthopedic limitation preventing exercise testing
- Extracardiac or congenital abnormality limiting the participant's functional ability to exercise
- Pregnant
Who the study is looking for
- 10 - 18 year olds followed at the Stollery Children's Hospital
- Heart transplant recipients ≥6 months post-transplant
- Have a moderate-complex congenital heart disease diagnosis
Age in the registry: 10 years to 18 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Alberta Coordinator of this site? Confirm its status | Edmonton | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.