NCT06330038RecruitingPhase 4
Anesthesia and Non-small Cell Lung Cancer Recurrence
Recurrence Free Survival After Curative Resection of Non-small Cell Lung Cancer Between Inhalational Gas Anesthesia and Propofol-based Total IntraVenous Anesthesia: a Multicenter, Randomized, Clinical Trial
Source: ClinicalTrials.gov · Last updated 20 Apr 2026
Brief summary (registry, in English)
There has been ongoing debate about the relationship between cancer recurrence and anesthetic management. Therefore, the investigators will test the hypothesis that the recurrence free survival (RFS) after curative resection of NSCLC is higher in patient who received total intravenous anesthesia (TIVA) than volatile anesthetics in this multi-center randomized trials.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 5384 (estimated)
- First submitted
- 19 Mar 2024
- Start date
- 5 Aug 2024
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- Samsung Medical Center
- Diseases
- Lung cancer
- NCT number
- NCT06330038
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 5384
- From 5 Aug 2024 to the primary completion date, 31 Dec 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous surgery due to lung cancer (except diagnostic biopsies)
- Surgery under cardiopulmonary bypass or extracorporeal membrane oxygenation
Other illness
- Distant metastasis or malignant tumor in other organs that according to the attending surgeon is not in long-term remission
- Severe neurologic conditions
- Severe hepatic disease (Child-Pugh classification C)
- Renal failure requiring renal replacement therapy
- History of anesthesia and/or surgery within 1 yr
- Contraindications to any study medication (history of allergy, hypersensitivity reaction, or any other contraindication)
Other
- Planned joint extrapulmonary procedure
- Postoperative sedation
- Pregnancy, or lactation
- Patient refusal.
Who the study is looking for
- American Society of Anesthesiologists physical status (ASA) Ⅰ-Ⅲ
- The Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Lung resection surgery (segmentectomy, lobectomy, bilobectomy, pneumonectomy; video-assisted, robot-assisted, or open) with curative intent for NSCLC (clinical Tumor, Node, Metastasis (TNM) stage Ⅰ- ⅢA).
Age in the registry: 19 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Samsung Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.