NCT06331572Completed
Exploring Blood Plasma Metabolomics: Unraveling the Metabolic Landscape in Treatment-Resistant Adolescent Depression
Source: ClinicalTrials.gov · Last updated 26 Mar 2024
Brief summary (registry, in English)
This study contributes new evidence for the identification of adolescent TRD and sheds light on differing pathophysiologies by delineating distinct plasma metabolic profiles between adolescent TRD and FEDN-MDD.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 162 (actual)
- First submitted
- 20 Mar 2024
- Start date
- 1 Aug 2021
- Primary completion date
- 25 Oct 2021
- Lead sponsor
- First Affiliated Hospital of Chongqing Medical University
- Diseases
- Depression
- NCT number
- NCT06331572
What you commit to
- Study type: Observational
- Participants enrolled: 162
- From 1 Aug 2021 to the primary completion date, 25 Oct 2021
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- the presence or past history of severe medical, neurological or psychiatric disorders (other than MDD in patients)
- Chronic physical diseases that significantly affect peripheral metabolism or neurological function
- the presence or past history of severe medical, neurological or psychiatric disorders
- Chronic physical diseases that significantly affect peripheral metabolism or neurological function
Other
- FEDN-MDD、TRD：
- anxiety comorbidity was not considered an exclusion criterion provided that MDD was the main diagnosis and the primary reason for seeking assistance
- substance abuse, head trauma, or loss of consciousness
- Pregnant and lactating women
- HC:
- substance abuse, head trauma, or loss of consciousness
- Pregnant and lactating women
Who the study is looking for
- FEDN-MDD：
- Age 12-18 years
- Meet the diagnostic criteria for MDD according to the DSM-5
- First-episode and drug-naive
- HAMD-17 score \> 17
- TRD:
- Age 12-18 years
- Meet the diagnostic criteria for MDD according to the DSM-5
- HAMD-17 score \> 13
- Currently or previously taking a standard therapeutic dose of antidepressant for at least 6 weeks, and they had at least one historical failure to an antidepressant (reduction in depressive symptoms \<50%)
- HC:
- age 12-18 years
- HAMD-17 score \< 7
- HCs without a personal history of a mental illness or family history in a first-degree relative
Age in the registry: 12 years to 18 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First Affiliated Hospital of Chongqing Medical University Coordinator of this site? Confirm its status | Chongqing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.