NCT06331676Recruiting
Developing a Complex ex Vivo Endometrial Tissue Model to Improve Endometriosis Care
Developing a Complex ex Vivo Endometrial Tissue Model Based on Patient Biopsies to Assess and Optimise the Response to Current and Potential Treatments for Endometriosis
Source: ClinicalTrials.gov · Last updated 30 Jan 2026
Brief summary (registry, in English)
Endometriosis is a chronic gynaecological disease characterised by the growth of endometrium outside the uterus. It affects 10% of childbearing age women. There is no cure for endometriosis. Hormonal treatments should be the first line therapy. The benefit-risk ratio of symptomatic treatment with hormone therapy varies greatly from one woman to another. The pathophysiology of endometriosis and the mechanisms of action of these treatments are still poorly understood. This may be due to the lack of an optimal experimental model for studying the disease. The aim of this project is to develop a complex ex vivo endometrial model recapitulating the organisation and properties of the human endometrium using innovative tissue bioengineering methods. This model will make it possible to develop a pre-clinical approach that predicts individual response to different types of hormonal treatment in order to optimise therapeutic choices and provide a better understanding of the effects of these treatments.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 90 (estimated)
- First submitted
- 9 Feb 2024
- Start date
- 21 Jun 2024
- Primary completion date
- 21 Mar 2028
- Lead sponsor
- Hospices Civils de Lyon
- Diseases
- Endometriosis
- NCT number
- NCT06331676
What you commit to
- Study type: Interventional
- Planned participants: 90
- From 21 Jun 2024 to the primary completion date, 21 Mar 2028
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Pregnant at the time of sampling or within 3 months prior to sampling
- Anyone who has received hormonal treatment with hormones other than steroids in the three months prior to sampling
Other illness
- Anyone with a personal history of cancer of the breast, ovary, endometrium or cervix
- People with Lynch syndrome
Other
- Breast-feeding women
- Women undergoing physiological menopause
- Anyone with a non-hormonal contraceptive intrauterine device (copper coil)
- Persons under legal protection (guardianship, curatorship)
- Persons deprived of their liberty by judicial or administrative decision
- Persons with a body mass index (BMI) of less than 18.5 or more than 30
Who the study is looking for
- Female
- People aged between 18 and 50
- Person who has or has had hormonal contraceptive treatment
- A person who has given written consent
- Person diagnosed with a benign gynaecological pathology not affecting the endometrium and requiring hysterectomy, hysteroscopy or laparoscopy or with a diagnosis of endometriosis and requiring laparoscopy or hysterectomy
- Person affiliated to the french social security
Age in the registry: 18 years to 50 years · Sex: Female · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hôpital Femme Mère Enfant / GHE Coordinator of this site? Confirm its status | Bron | France | Recruiting |
| Hôpital de la Croix-Rousse / GHN Coordinator of this site? Confirm its status | Lyon | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.