NCT06333665Completed
PPIO-007 Correlation Analysis of Type II Diabetes Mellitus on Short-term and Long-term Outcomes of Patients With Esophageal Squamous Cell Cancer Undergoing Minimally Invasive Esophagectomy
Correlation Analysis of Type II Diabetes Mellitus on Short-term and Long-term Outcomes of Patients With Esophageal Squamous Cell Cancer Undergoing Minimally Invasive Esophagectomy
Source: ClinicalTrials.gov · Last updated 30 Sept 2025
Brief summary (registry, in English)
To date, there is controversy as to whether type II diabetes mellitus is associated with adverse short- and long-term outcomes in patients with esophageal squamous cell carcinoma undergoing minimally invasive esophagectomy. At the same time, to the best of our knowledge, the impact of metformin use and glycemic control on short- and long-term outcomes in this patient population is also controversial. Therefore, this study aims to test the hypothesis that diabetes mellitus is associated with reduced survival in patients with esophageal squamous cell carcinoma undergoing minimally invasive esophagectomy and that treatment with metformin and/or good glycemic control (HbA1c\<7.0%) is associated with improved survival.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 605 (actual)
- First submitted
- 21 Mar 2024
- Start date
- Feb 2024
- Primary completion date
- Apr 2024
- Lead sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
- NCT number
- NCT06333665
What you commit to
- Study type: Observational
- Participants enrolled: 605
- From Feb 2024 to the primary completion date, Apr 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concomitant history of other primary cancers or other cancers;
- Distant metastases before surgery;
- Serious comorbidities of other systems before surgery;
Other
- Patients diagnosed with T2DM during follow-up;
- The medical record information is incomplete.
Who the study is looking for
- Patients with a clear pathologic diagnosis of esophageal squamous cell carcinoma;
- Received minimally invasive McKeown procedure;
- Patients with R0 resection (R0: radical resection).
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Army Medical Center of the People's Liberation Army Coordinator of this site? Confirm its status | Chongqing | China | Unknown status |
Related publications
- Type 2 diabetes mellitus confers unfavorable short- and long-term outcomes in patients undergoing esophagectomy.Surg Endosc · 2026 · PMID 42493614
This page is information, not medical advice. Discuss any trial with your doctor.