Faecal Microbiota Transplantation Against Chronic Diarrhea in Patients With Systemic Sclerosis

Prior treatment

• Previous treatment with FMT
• Treatment with antibiotics within the past 6 weeks
• Dysregulated thyroid disease (TSH) blood sample from previous consultations maximum 6 months old from
• Previous abdominal surgery (minor surgical procedures ex. appendectomy is allowed)

Other illness

• Ongoing infection with Clostridioides difficile (negative PCR test)
• Known serious gastrointestinal disease or GI infection (diagnosed with e.g. inflammatory bowel disease and/or gastrointestinal cancer)

Lab values

• Known Severe end-organ disease
  • Lung disease with forced vital capacity(FVC)\<50% and/or diffusing lung capacity for carbon monoxide (DLCO) \<40%
  • Severe heart failure with ejection fraction \<30%
  • End-stage kidney disease with glomeration rate\<30ml/min

Other

• Inability to understand Danish spoken or written and/or Trial procedures.
• Known or anticipated pregnancy (excluded by male sex, postmenopausal women, or otherwise negative U-HCG)
• Changes in morphine treatment within the past 4 weeks
• Known intestinal stricture
• Planned MR scan within the study period
• Pacemaker/ICD
• Changes in medicine that affect the GI tract within the past four weeks.

• Participants \> 18 years
• Fulfilling and previously diagnosed with SSc according to the 2013 American College of Rheumatology/European League against rheumatisms SSs classification criteria\[23\] by rheumatologist or dermatologist.
• Chronic diarrea is defined as loose or watery stools, three or more times a day, a minimum of 50% of the days within the last four weeks.