NCT06335420Recruiting
Prophylactic Properties of Carrot Juice in Patients With High-Risk Colorectal Polyps
Polyp Prophylactic Properties of Polyacetylenes in Patients With Previous Polypectomy
Source: ClinicalTrials.gov · Last updated 20 Nov 2025
Brief summary (registry, in English)
The goal of this prospective randomized double-blinded bi-national study is to test the prophylactic effect of polyacetylenes from carrots on the population of patients who had a resection of high-risk adenomas of the large bowel. The main question it aims to answer is: Will carrot juice rich in polyacetylenes inhibit neoplastic transformation and growth in high-risk humans? Participants will have to drink 100 ml of juice daily after the adenoma resection for 1 year and keep a simple diary/calendar. Researchers will compare the group with ingestion of Falcarinol (FaOH) / Falcarindiol (FaDOH) rich carrot juice versus the group consuming placebo juice, to see if the polyacetylenes significantly reduces neoplastic transformation and growth in high-risk patients.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 400 (estimated)
- First submitted
- 13 Mar 2024
- Start date
- 20 Jun 2024
- Primary completion date
- 1 Jun 2027
- Lead sponsor
- Odense University Hospital
- Diseases
- Colorectal cancer
- NCT number
- NCT06335420
What you commit to
- Study type: Interventional
- Planned participants: 400
- From 20 Jun 2024 to the primary completion date, 1 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Chronic consumption of COX (cyclooxygenase) inhibitors (Aspirin, Celecoxib, Ibuprofen, Diclofenac, Ketoprofen, Ketorolac, Indometacin, Naproxen, Piroxicam) or immunosuppressive agents (Methotrexate, Azathioprine or glucocorticoids).
Other illness
- Known relevant allergies.
- Patients with different neoplastic disease under treatment (Chemo-/Radio-/Imunotherapy).
- Lynch syndrome.
Other
- Patients allocated to "high-risk" group because of many small polyps (\>4).
- Pregnancy.
- Severe comorbidity NYHA III-IV.
Who the study is looking for
- Any type of resection for adenomas larger than 20 mm in size (endoscopically evaluated) or endoscopically resected T1 cancers.
- Acceptance of the treatment and follow-up program.
- Capability to understand and follow the instructions.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Surgery, Odense University Hospital Coordinator of this site? Confirm its status | Odense | Denmark | Recruiting |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.