NCT06335953Completed
ALIGN: Aligning Medications With What Matters Most (Demonstration)
Demonstration of ALIGN: Aligning Medications With What Matters Most
Source: ClinicalTrials.gov · Last updated 6 Aug 2026
Brief summary (registry, in English)
The goal of this clinical trial is to test the effectiveness of a pharmacist-led, primary care-based de-prescribing intervention for people living with dementia (PLWD) and the person's care partners. The intervention consists of the following strategies: 1) a de-prescribing educational brochure designed to activate the patient and care partner; 2) a single telehealth visit in which an embedded clinical pharmacist discusses the benefits and harms of the patient's medications with the patient and care partner in the context of the person's goals and preferences; and 3) pharmacist-PCP communication in which the pharmacist provides tailored de-prescribing recommendations designed to be useful and actionable for the PCP. The investigators will compare the intervention group with the waitlist control group to see if there is a difference in the primary outcome, the proportion of patients who deprescribe at least one medication by 3 months.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 474 (actual)
- First submitted
- 22 Mar 2024
- Start date
- 7 May 2024
- Primary completion date
- 16 Sept 2025
- Lead sponsor
- Johns Hopkins University
- Diseases
- Alzheimer disease
- NCT number
- NCT06335953
What you commit to
- Study type: Interventional
- Participants enrolled: 474
- From 7 May 2024 to the primary completion date, 16 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- As the pragmatic trial will be based on primary care, individuals residing in long-term care facilities or enrolled in hospice will be excluded.
- Participants must hear well enough to communicate by telephone in English.
Who the study is looking for
- Age ≥65 years
- Diagnosis of dementia from International Classification of Diseases (ICD-10) visit codes or from the EHR problem list
- Five or more medications
- Only active patients, defined as having \>1 visit to the primary care clinic within the past year will be included
- Care partners:
- Family or other companions \>21 years old who regularly help the patient manage medications.
Age in the registry: 65 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Johns Hopkins Community Physicians Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.