NCT06335992Recruiting
Tissue Regeneration in Patients With Chronic Obstructive Pulmonary Disease After an Exercise Intervention.
Activation of Regenerative Pathways by Exercise Training in Patients With Chronic Obstructive Pulmonary Disease
Source: ClinicalTrials.gov · Last updated 19 Aug 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The main objective of this project is to identify mechanisms for lung regeneration in patients with COPD induced by exercise training. The hypothesis is that adjusted exercise training improves disease outcome in these patients by decrease remodelling processes linked to oxidative stress, inflammatory and/or immunological pathways in the lung. Along the way, the investigator also expect to identify (or validate) biomarkers mirroring systemic processes such as reduced inflammation and ameliorating the epithelial barrier in these patients. These events may additionally act as potential targets for interventions. Objectives (i) Evaluate biomarkers for regenerative processes, matrix turnover, stem cell activity and inflammatory patterns in lung tissue biopsies, blood- and urine samples correlated to vital lung parameters and physical capacity, before and after attending an exercise-training program. (ii) Study the effects of exercise training on the pulmonary ventilation/perfusion ratio and quality of life. (iii) Evaluate the relation between pathophysiology in the lung evaluated by CT scan, and systemic response measured by muscle biopsies and biomarkers in blood/urine. (iv) Investigate in vitro cell behaviour and remodelling/regenerative processes altered in COPD patients upon exercise training (aim 1).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- First submitted
- 7 Mar 2024
- Start date
- 1 Sept 2022
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- Uppsala University
- Diseases
- COPD
- NCT number
- NCT06335992
What you commit to
- Study type: Interventional
- Planned participants: 80
- From 1 Sept 2022 to the primary completion date, 31 Dec 2025
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Unstable cardiovascular or pulmonary disease
Other
- Regular participation in adjusted/specially designed exercise sessions
- Smoking
- Any other criteria that at the discretion of the investigator prevent the study subject from participating in an exercise-training program
Who the study is looking for
- Forced expiratory volume in one second (FEV1) 85-30 % of predicted post bronchodilator
- Optimal medical treatment according to GOLD and the Swedish National Guidelines
- Absence of other significant diseases that could contribute to physical exercise limitation
- Non-smoking since at least one year
- Free from exacerbations (last 4 weeks)
- BMI = 18- 35
Age in the registry: 50 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Lund University Coordinator of this site? Confirm its status | Lund | Sweden | Recruiting |
| Uppsala University Coordinator of this site? Confirm its status | Uppsala | Sweden | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.