NCT06339190Recruiting
Neurofilament Light Chain And Voice Acoustic Analyses In Dementia Diagnosis
A Blood Test for Dementia? A Cohort Study to Assess the Diagnostic Utility of Plasma Neurofilament Light Chain Protein in All-cause Dementia
Source: ClinicalTrials.gov · Last updated 8 Oct 2026
Brief summary (registry, in English)
This cohort study aims to determine if a blood test can aid with diagnosing dementia in anyone presenting with cognitive complaints to a single healthcare network. The investigators will measure levels of a brain protein, Neurofilament light chain (Nfl), and assess changes in language using speech tests. Participants will have a single blood test and speech test, and will be followed up at 12-months to complete questionnaires and cognitive scales over the phone. The speech test will also be completed again at 12-months. Individuals at risk of a genetic dementia syndrome will be eligible to complete optional genetic testing involving an 'at home' saliva sample.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 1000 (estimated)
- First submitted
- 21 Sept 2023
- Start date
- 1 Aug 2021
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- Monash University
- Diseases
- Alzheimer disease
- NCT number
- NCT06339190
What you commit to
- Study type: Observational
- Planned participants: 1000
- From 1 Aug 2021 to the primary completion date, 31 Mar 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Prognosis \<12 months
- No cognitive complaint
- Patients not involved within the single healthcare network
Who the study is looking for
- All patients presenting to Eastern Health services with a cognitive complaint or potential neurodegenerative disorder
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Box Hill Hospital Coordinator of this site? Confirm its status | Box Hill | Australia | Recruiting |
| Wantirna Health Coordinator of this site? Confirm its status | Wantirna | Australia | Recruiting |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.