NCT06342414Recruiting
An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer
Source: ClinicalTrials.gov · Last updated 7 Jul 2026
Brief summary (registry, in English)
It is sometimes difficult to precisely understand whether a primary liver cancer is a hepatocellular carcinoma or a cholangiocarcinoma. The researchers will develop and validate a liquid biopsy, based on exosomal content analysis and powered by machine learning, to help clinicians differentiate these two cancers before surgery.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 400 (estimated)
- First submitted
- 26 Mar 2024
- Start date
- 15 Mar 2024
- Primary completion date
- 18 Jun 2028
- Lead sponsor
- City of Hope Medical Center
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT06342414
What you commit to
- Study type: Observational
- Planned participants: 400
- From 15 Mar 2024 to the primary completion date, 18 Jun 2028
- 5 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Primary liver cancer other than hepatocellular carcinoma or intrahepatic cholangiocarcinoma
- Secondary liver cancer
Other
- Lack of or inability to provide informed consent
- Synchronous hepatocellular carcinoma and intrahepatic cholangiocarcinoma
Who the study is looking for
- A histologically confirmed diagnosis of hepatocellular carcinoma
- A histologically confirmed diagnosis of intrahepatic cholangiocarcinoma
- Received standard diagnostic and staging procedures as per local guidelines
- Availability of at least one blood-derived sample, drawn before receiving any curative-intent treatment
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Graduate School of Medical Sciences, Kyushu University Coordinator of this site? Confirm its status | Fukuoka | Japan | Recruiting |
| Graduate School of Medical Sciences, Kumamoto University Coordinator of this site? Confirm its status | Kumamoto | Japan | Recruiting |
| Hokkaido University Graduate School of Medicine Coordinator of this site? Confirm its status | Sapporo | Japan | Recruiting |
| Tokushima University Coordinator of this site? Confirm its status | Tokushima | Japan | Recruiting |
| City of Hope Medical Center Coordinator of this site? Confirm its status | Duarte | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.