NCT06342440Recruiting
Early Detection of Advanced Adenomas and Colorectal Cancer
A Liquid Biopsy Assay For The Non-Invasive Early Detection of Advanced Adenomas and Colorectal Cancer
Source: ClinicalTrials.gov · Last updated 7 Jul 2026
Brief summary (registry, in English)
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 2000 (estimated)
- First submitted
- 26 Mar 2024
- Start date
- 15 Mar 2020
- Primary completion date
- 18 Jun 2028
- Lead sponsor
- City of Hope Medical Center
- Diseases
- Colorectal cancer
- NCT number
- NCT06342440
What you commit to
- Study type: Observational
- Planned participants: 2000
- From 15 Mar 2020 to the primary completion date, 18 Jun 2028
- 6 sites in 5 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Hereditary colorectal cancer syndromes (identified through genetic testing).
- Inflammatory bowel diseases.
Other
- Lack of written informed consent.
Who the study is looking for
- All individuals included in the study need to have had a colonoscopy at the time of blood sampling.
- Received standard diagnostic and staging (as necessary) procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment.
- Received standard pathological and endoscopic diagnosis and assessment for cohort assignment.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (6)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First Affiliated Hospital of Dalian Medical University Coordinator of this site? Confirm its status | Dalian | China | Recruiting |
| Barcelona University Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| IRCCS San Raffaele Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
| Mie University Coordinator of this site? Confirm its status | Mie | Japan | Recruiting |
| City of Hope Medical Center Coordinator of this site? Confirm its status | Monrovia | United States | Recruiting |
| University of California San Diego Coordinator of this site? Confirm its status | San Diego | United States | Recruiting |
Related publications
- A blood-based test for detection of advanced adenomas and colorectal cancer (DENEB): a multicentre diagnostic accuracy study.Lancet Gastroenterol Hepatol · 2026 · PMID 42575119
This page is information, not medical advice. Discuss any trial with your doctor.