NCT06346054Recruiting
Molecular Assessment for Gastro-Esophageal Cancer
Source: ClinicalTrials.gov · Last updated 17 Feb 2026
Brief summary (registry, in English)
The goal of this minimally invasive interventional study is to learn if oncometabolic biomarkers, detected in the exhaled breath and blood can identify early-stage gastro-oesophageal cancer in patient at risk for gastro-oesophageal cancer. The main questions this study aims to answer: Are oncometabolites proficient and reproducible enough to function as diagnostic biomarkers? Can these biomarkers identify early-stage gastro-esophageal cancer? Researchers will compare participants with gastro-oesophageal cancer to healthy controls and participants with Barrett's esophagus to detect meaningful differences between the groups. Participants will provide a breath and blood sample during their routine standard of care visits.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 1000 (estimated)
- First submitted
- 23 Mar 2024
- Start date
- 1 Aug 2024
- Primary completion date
- 1 Jul 2029
- Lead sponsor
- KU Leuven
- Diseases
- Gastric and esophageal cancer
- NCT number
- NCT06346054
What you commit to
- Study type: Interventional
- Planned participants: 1000
- From 1 Aug 2024 to the primary completion date, 1 Jul 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any disorder, which in the investigator's opinion might jeopardise participant's safety or compliance with the study plan.
Age
- \<18 years old
- Patient has history of:
- Active other cancer than gastro-esophageal cancer
- Prior cancer treated \<3 years ago
- Hepatic dysfunction/liver failure (MELT \>7)
Other
- Insufficient/unreliable quality of breath (e.g., breath flow) or plasma sample (e.g., haemolytic sample)
- Incarcerated individuals
Who the study is looking for
- Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any breath or blood analysis
- \>18 years old
- Barrett's esophagus or treatment naïve gastro-esophageal cancer stage I to IV
- Voluntary healthy controls
Age in the registry: 18 years to 100 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospitals Leuven Coordinator of this site? Confirm its status | Leuven | Belgium | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.