NCT06350617Recruiting
Personalized rTMS Protocol Based on Functional Reserve to Enhance Ambulatory Function in PD Patients
Safety and Efficacy of Personalized Repetitive Transcranial Magnetic Stimulation Protocol Based on Functional Reserve to Enhance Ambulatory Function in Patients With Parkinson Disease
Source: ClinicalTrials.gov · Last updated 28 Apr 2026
Brief summary (registry, in English)
The objective of this study was to determine the effects of protocols of repetitive transcranial magnetic stimulation (rTMS) therapy based on the functional reserve of each patient with Parkinson's disease, compared to conventional high-frequency rTMS therapy on bilateral primary motor cortex (M1). Investigators hypothesized that the functional reserve of each patient with Parkinson's disease will be different, and therefore an appropriate simulating target for rTMS therapy is needed. In addition, this approach could be more effective compared to conventional protocols applied to patient with Parkinson's disease regardless of their severity, predicted mechanism of motor function recovery, or functional reserves.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 27 Feb 2024
- Start date
- 20 Feb 2024
- Primary completion date
- 30 Sept 2026
- Lead sponsor
- Samsung Medical Center
- Diseases
- Parkinson disease
- NCT number
- NCT06350617
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 20 Feb 2024 to the primary completion date, 30 Sept 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- those with contraindications to rTMS, such as epilepsy, implanted metal objects in the head, or a history of craniotomy,
- those with cognitive impairment, confirmed through the Montreal Cognitive Assessment (MoCA) test as follows: \< 7 points: Illiterate \< 13 points: Education duration 0.5-3 years \< 16 points: Education duration 4-6 years \< 19 points: Education duration 7-9 years \< 20 points: Education duration 10 years or more
- those with coexisting neurological conditions, such as spinal cord injury or Stroke,
- those with major psychiatric disorders, such as major depression, schizophrenia, or dementia,
Other
- those with severe on-off phenomena or severe dyskinesia, deemed by the investigators to render participation in the study inappropriate.
- those having contraindications to conduct an MRI study,
- those who are pregnant or lactating,
- patients who have refused to participate in this study.
Who the study is looking for
- patients with Parkinson's disease, diagnosed by the United Kingdom (UK) Parkinson's Disease Society Brain Bank Diagnostic Criteria,
- Modified Hoehn and Yahr (H\&Y) scale, stage 2\~4,
- patients who can walk on flat surfaces without the need for a gait aid,
- aged ≥50 years old,
- patients willing to sign the informed consent.
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Samsung Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.