NCT06350929Recruiting
Norepinephrine in the Management of General Anesthesia-Induced Arterial Hypotension in Chronic Heart Failure Patients
Evaluation of Norepinephrine in the Management of General Anesthesia-Induced Arterial Hypotension in Chronic Heart Failure Patients in the Operating Room.
Source: ClinicalTrials.gov · Last updated 5 Nov 2026
Brief summary (registry, in English)
Arterial hypotension is a frequent complication of general anesthesia and a significant contributor to postoperative complications. It is a critical marker for the development of acute renal failure and postoperative myocardial infarction. Chronic heart failure (CHF) patients are increasingly encountered in the operating room, and their perioperative morbidity and mortality are substantial, with specific management lacking precise recommendations. The main objective is to assess the impact of a diluted norepinephrine bolus on cardiac output in chronic heart failure patients experiencing arterial hypotension after anesthesia induction.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 50 (estimated)
- First submitted
- 28 Mar 2024
- Start date
- 17 Oct 2024
- Primary completion date
- Dec 2026
- Lead sponsor
- University Hospital, Toulouse
- Diseases
- Heart failure
- NCT number
- NCT06350929
What you commit to
- Study type: Observational
- Planned participants: 50
- From 17 Oct 2024 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients treated with catecholamines prior to the procedure.
Other illness
- Chronic heart failure patients with right ventricular failure.
- Patients presenting signs of acute pulmonary edema, Pulmonary arterial hypertension (PAH), severe valvular disease, intracardiac shunt.
- Patients with respiratory compliance disorders with compliances greater than 30 cm of water.
- Patients with intra-abdominal hypertension.
- Patients with supraventricular or ventricular arrhythmia.
Other
- Patients operated on under general anesthesia but maintaining spontaneous ventilation.
- Patients operated on for urgent surgeries
- Patient under guardianship, curatorship or safeguard of justice
- Pregnant or breastfeeding women.
Who the study is looking for
- Adult patients
- Heart failure patients with left ventricular failure with a ventricular ejection fraction less than or equal to 40% evaluated by trans-thoracic echocardiography less than a year ago and specifying in particular the patient's filling pressures at the state stable.
- Patients under treatment adapted to the level of heart failure according to the 2021 European Society of Cardiology recommendations.
- Scheduled surgery under general anesthesia.
- Invasive hemodynamic monitoring planned by the anesthetist-resuscitator (irrespective of potential inclusion in the protocol): arterial catheter and central venous line for measurement of CVP (central venous pressure).
- Postoperative monitoring planned in intensive care or intensive care
- Presence of controlled mechanical ventilation with tidal volumes between 8 and 10 ml/kg of ideal weight.
- Presence of arterial hypotension after induction of general anesthesia, and before surgical stimulation.
- Patient affiliated to a social security scheme or equivalent
- No opposition from the patient.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU Toulouse-Rangueil Coordinator of this site? Confirm its status | Toulouse | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.