NCT06351462Not yet recruiting
Comparative Health Status and Quality of Life of Patients With Sickle Cell Disease (SCD) Who Underwent Matched-sibling Hematopoietic Stem Cell Transplantation Versus Non Transplanted SCD Case-control Patients
Source: ClinicalTrials.gov · Last updated 19 Apr 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The long term burden of morbidity and mortality in the natural history of sickle cell disease has not been compared up to date to the risks and mortality of a curative option like bone marrow transplantation in severe sickle-cell disease patients. Given this lack of data, primary-care Sickle Cell Disease (SCD) physicians and transplant physicians are prevented from a factual debate over the benefit/risk ratio for each patient and refining indications of transplant in patients. Therefore, the present study seeks to describe and compare the very long-term outcomes after either Human Leukocyte Antigen (HLA) -matched sibling transplantation (study arm) and "non-transplant care" for severe sickle cell disease SCA patients in order to yield robust comparative data regarding both arms. The main objective is to assess the benefit of Hematopoietic stem cell transplantation (HSCT) regarding quality of life compared to standard care after 10 years, in patients with severe Sickle Cell Disease (SCD).
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 220 (estimated)
- First submitted
- 2 Apr 2024
- Start date
- 1 May 2024
- Primary completion date
- 1 May 2027
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Diseases
- Sickle cell disease
- NCT number
- NCT06351462
What you commit to
- Study type: Interventional
- Planned participants: 220
- From 1 May 2024 to the primary completion date, 1 May 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Transplantation from donor other than sibling or related cord-blood
Other illness
- Having any debilitating medical or psychiatric illness, which preclude understanding of the inform consent as well as optimal treatment and follow-up
Other
- Study population:
- Conditioning regimen other than busulfan 16mg/kg total dose + cyclophosphamide 200mg/kg total dose + anti-thymoglobuline
- For both population:
- Absence of signed informed consent
Who the study is looking for
- Study population (exposed-patients), all criteria should be fulfilled:
- Patients alive with Sickle Cell Anemia (SCA, meaning SS and Sbeta0 sickle cell anemia genotype)
- Patients transplanted from allogeneic HLA-compatible sibling donor or from sibling cord blood unit from the 1st of January 2000 and the 31st of December 2012, whatever the age at transplant
- Patients having received conditioning regimen containing busulfan 1mg/kg/dose (or equivalent adjusted body-weight dosage according to recommendation) x 16 doses + cyclophosphamide 200mg/kg total dose + anti-thymoglobuline
- For patient under 18 years at time of enrolment, signed informed consent from both parental representatives
- For patient aged 18 years old : signed informed consent
- Having an affiliation to a social security regime
- Control-population (Non-exposed patients) :
- For each allografted patient, one non-exposed patient will be matched, based on the following criteria:
- Gender
- Age at the date of transplantation of the exposed patient (+/- 1 year)
- Foetal hemoglobin (HbF) level (+/- 3%) before treatment intensification (defined as the initiation of either hydroxyurea or a transfusion program)
- Hb level (+/- 0,9 g/dl) before treatment intensification
- For patient under 18 years at time of enrolment, signed informed consent from both parental representatives
- For patient above 18 years of age: signed informed consent
- Having an affiliation of to a social security regime
Age in the registry: 15 years to 80 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.