NCT06353620Recruiting
Structural-functional Connectome in Drug-resistant Epilepsies and Neurodevelopmental Syndromes With Epilepsy
Structural-functional Connectome With High-density Electroencephalography in Drug-resistant Epilepsies and Rare Neurodevelopmental Syndromes With Epilepsy
Source: ClinicalTrials.gov · Last updated 9 Apr 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Recent studies have shown that the aperiodic part of the signal (neuronal avalanches) of electroencephalography (EEG) contains important information about the dynamics of neuronal networks. Indeed, this has helped to identify functionally altered areas in patients with temporal epilepsy by simply using the resting EEG signal. Furthermore, it has been seen that the propagation of neuronal avalanches (VNs) correlates with the morphological organization of the cerebral cortex. Therefore, NAs represent a measure with direct utility for studying functional reorganization pre and post drug/surgical treatment. In addition, the aperiodic portion of the signal may represent a noninvasive measure of the excitation/inhibition relationship, which is known of being altered both in epilepsy and in some rare neurodevelopmental syndromes (example: Angelman and Dup15q)
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 120 (estimated)
- First submitted
- 20 Mar 2024
- Start date
- 13 Feb 2024
- Primary completion date
- 18 Mar 2024
- Lead sponsor
- IRCCS Eugenio Medea
- Diseases
- Epilepsy
- NCT number
- NCT06353620
What you commit to
- Study type: Observational
- Planned participants: 120
- From 13 Feb 2024 to the primary completion date, 18 Mar 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- vascular causes or non-low-grade tumors as causes of epilepsy;
Age
- age different from the range 6-75 years;
Other
- neuroradiological examination not complete (absence T1 3D);
- absence of HD-EEG 128-channel recording
- inability to take part in a neuropsychological evaluation.
Who the study is looking for
- a diagnosis of focal or generalized epilepsy, Angelman syndrome, or Dup15q, confirmed by specialist evaluation;
- at least one MRI scan of the brain that includes 3D T1 sequences;
- at least one 128-channel HD-EEG recording; and
- age between 6 and 75 years at the time of the evaluation of the present study;
- ability to take part in a neuropsychological evaluation.
Age in the registry: 6 years to 75 years · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| IRCCS E. Medea Coordinator of this site? Confirm its status | Conegliano | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.