NCT06354322Recruiting
Unclassified GENotypes of Autoinflammatory Diseases and AA Amyloidosis
Physiopathological Investigation of Unclassified GENotypes of Autoinflammatory Diseases and AA Amyloidosis
Source: ClinicalTrials.gov · Last updated 2 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Patients with autoinflammatory diseases (AID) have recurrent episodes of systemic inflammation accompanied by nonspecific elevation of blood inflammation markers typically absent between attacks. A complication of autoinflammatory diseases is AA amyloidosis, which can lead to renal failure and dialysis. Advances in genetic analysis have led to the identification of new autoinflammatory diseases and thus new pathophysiological pathways. However, genetic analyses are sometimes confronted with results that are difficult to interpret. These are the Variants of Unknown Significance, for which genetic analysis alone does not allow to determine if the genetic mutation is responsible for the symptoms. genetic analysis sometimes has limitations in the diagnosis of AID which can only be overcome by pathophysiological studies of the variants found.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 3 Apr 2024
- Start date
- 26 Feb 2025
- Primary completion date
- Feb 2039
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Diseases
- Amyloidosis
- NCT number
- NCT06354322
What you commit to
- Study type: Observational
- Planned participants: 200
- From 26 Feb 2025 to the primary completion date, Feb 2039
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Patients unable to give express free and informed consent;
- Subjects under guardianship, curatorship or safeguard of justice;
- Subjects who do not speak French;
- Subjects unable to answer questions or express themselves;
- Patients weighing less than 15 kg;
- Patients without social security coverage
Who the study is looking for
- Patients over 18 years of age with the capacity to give express free and informed consent and;
- Minor patients under 18 years of age with both parents or legal guardians giving consent;
- Patients with unclassified IAD or AA amyloidosis of undetermined etiology;
- Patients followed in one of the study departments;
- Patients weighing more than 15 kg.
- Patients over 18 years of age with the capacity to give free and informed express consent;
- Patients with IAD classified with well-defined international criteria or ;
- Patients who have undergone cosmetic surgery or blood donors).
Age in the registry: 3 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Service médecine interne-Hôpital Tenon Coordinator of this site? Confirm its status | Paris | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.