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NCT06355986Not yet recruiting

Computerized Decision Support to Prevent Stroke in Atrial Fibrillation

Community-Based, Cluster-Randomized Trial of Electronic Alert-Based Computerized Decision Support to Prevent Stroke in High-Risk Ambulatory Patients With Atrial Fibrillation (AF-ALERT3)

Source: ClinicalTrials.gov · Last updated 25 Feb 2026

Brief summary (registry, in English)

Atrial fibrillation (AF) is the most preventable cause of stroke. However, despite widely available risk stratification tools, numerous options for oral anticoagulation, and evidence-based practice guidelines, anticoagulation for stroke prevention in AF is consistently under-prescribed. In a pair of observational cohort analyses within the Mass General Brigham (MGB) health system, prescription of anticoagulation for stroke prevention in AF was less frequent in ambulatory clinic patients than in those who were hospitalized at the time of assessment (46.9% vs. 57.2%). Two single academic medical center randomized controlled trials demonstrated success for increasing adherence to guideline recommendations for stroke prevention in AF. To address the feasibility and impact of a computerized decision support (CDS) strategy in the non-tertiary care, community medical center setting, this study will involve a multicenter, cluster-randomized controlled trial of a more sophisticated CDS focused not only on implementation stroke prevention but also on bleeding risk assessment and management.

Status (registry)
Not yet recruiting
Study type
Interventional
Enrollment
2500 (estimated)
First submitted
27 Mar 2024
Start date
30 Dec 2026
Primary completion date
30 Jul 2027
Lead sponsor
Brigham and Women's Hospital
NCT number
NCT06355986

What you commit to

  • Study type: Interventional
  • Planned participants: 2500
  • From 30 Dec 2026 to the primary completion date, 30 Jul 2027
  • 2 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Active prescription for anticoagulant therapy

Other

  • CHA2DS2VASc score \< 2 for males
  • CHA2DS2VASc score ≤ 2 for females

Who the study is looking for

  • Male and Female
  • Age ≥ 18 years
  • Problem list entry of atrial fibrillation or atrial flutter
  • CHA2DS2VASc score ≥ 2 for males
  • CHA2DS2VASc score ≥ 3 for females
  • No prescription for anticoagulant therapy

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (2)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Mass General Brigham
Coordinator of this site? Confirm its status
BostonUnited StatesUnknown status
St. Elizabeth Health
Coordinator of this site? Confirm its status
EdgewoodUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.