NCT06359509Not yet recruitingEarly phase 1
Study of SYS6020 in BCMA-positive Multiple Myeloma
A Phase І Study of BCMA-targeted Chimeric Antigen Receptor T Cell (SYS6020) Injection in Relapsed or Refractory Multiple Myeloma
Source: ClinicalTrials.gov · Last updated 11 Apr 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This is a multi-center, phase I trial that studies the efficacy and recommended dose of BCMA CART cells in treating patients with BCMA-positive multiple myeloma (MM) that have not respond or relapsed after chemotherapy. B-cell maturation antigen (BCMA), a cell surface protein expressed on malignant plasma cell, has emerged as a very selective antigen to be targeted in novel immunotherapy for MM.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 10 (estimated)
- First submitted
- 27 Mar 2024
- Start date
- 1 Apr 2024
- Primary completion date
- 31 May 2027
- Lead sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Diseases
- Multiple myeloma
- NCT number
- NCT06359509
What you commit to
- Study type: Interventional · Early phase 1
- Planned participants: 10
- From 1 Apr 2024 to the primary completion date, 31 May 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- 2\. Received any prior CAR-T therapy or BCMA targeted therapy;
- 3\. Patients who have received autologous hematopoietic stem cell transplantation (ASCT) within 12 weeks prior to monocyte collection or history of allogeneic stem cell transplantation;
- 6\. Patients who, in the judgment of the investigator, need but are unable to receive prophylactic treatment for Pneumocystis, Herpes Simplex Virus (HSV), or Herpes Zoster (VZV) prior to initiation of treatment, or Syphilis confirmatory positive;
- 7\. History of Bacillus Tuberculosis (TB) treatment within 2 years prior to first medication;
Other illness
- 1\. Patients with plasmacytic leukemia or Waldenstrom's macroglobulinemia or POEMS syndrome (polyneuropathy, organ enlargement, endocrinopathy, monoclonal protein and skin lesions) or amyloidosis at screening;
- 4\. A history of immunodeficiency, including a positive HIV antibody test;
- 5\. Hepatitis B surface antigen (HBsAg) positive and HBV-DNA above the lower limit of measurement or 1000 copies /mL (500 IU/mL), (whichever is lower), HCV antibody positive and HCV-RNA above the lower limit of measurement or 1000 copies /mL (whichever is lower);
- 8\. Patients with a history of interstitial lung disease and/or severe lung function impairment;
- 9\. Have an active bacterial, fungal, or viral infection;
- 10.A history of severe cardiovascular disease.
Who the study is looking for
- 1\. ≥ 18 years of age at the time of signing informed consent;
- 2\. Cytology or tissue biopsy meets diagnostic criteria for multiple myeloma (according to IMWG criteria);
- 3\. Bone marrow specimens confirmed positive BCMA expression in plasma cells and myeloma cells by immunohistochemistry or flow cytometry (\>5%);
- 4\. Have measurable disease by International Myeloma Working Group (IMWG) criteria based on one or more of the following findings:
- Serum M-protein≥ 1 g/dL（≥10 g/L）
- Urine M-protein ≥ 200 mg/24 hour
- Involved serum free light chain (FLCs) level≥10 mg/dL with FLCs abnormal ratio (\<0.26或\>1.65)
- 5\. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1;
- 6\. Diagnosis of MM with relapsed or refractory disease and have had at least 1 prior lines of therapy.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.