NCT06365060Recruiting
Screening for AL Amyloidosis in Smoldering Multiple Myeloma
Source: ClinicalTrials.gov · Last updated 26 Oct 2026
Brief summary (registry, in English)
In this multicenter study, we will recruit 400 patients 40 years of age or older at 15 centers with a diagnosis of smoldering multiple myeloma (SMM), a group of patients for whom standard of care is observation not treatment. The main goal of this study is to screen for the diagnosis of light-chain amyloidosis (AL) before the onset of symptomatic disease and to develop a training set for a likelihood algorithm.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 400 (estimated)
- First submitted
- 10 Apr 2024
- Start date
- 1 May 2024
- Primary completion date
- 27 Feb 2029
- Lead sponsor
- Tufts Medical Center
- Diseases
- Amyloidosis, Multiple myeloma
- NCT number
- NCT06365060
What you commit to
- Study type: Observational
- Planned participants: 400
- From 1 May 2024 to the primary completion date, 27 Feb 2029
- 13 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with a previous finding of amyloid in other biopsies will not be included
Age
- Patients younger than 40 years of age are not eligible
Other
- Adults unable to consent are not eligible, including the cognitively impaired Pregnant women, pregnant minors, minors (i.e., individuals who are not yet adults), wards of the state, non-viable neonates, neonates of uncertain viability, and prisoners are not eligible
Who the study is looking for
- Patients 40 years of age and older
- diagnosed with either Smoldering Multiple Myeloma or a Monoclonal Gammopathy
- dFLC greater than 23 mg/L
- abnormal FLC ratio
- If the patient has an eGFR less than 50 mL/min/1.73m2, the FLC ratio is inconsequential. The patient only needs to meet the age and dFLC criterion.
Age in the registry: 40 years to - · Sex: All · Does not accept healthy volunteers
Sites (13)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Alabama Hospital Coordinator of this site? Confirm its status | Birmingham | United States | Recruiting |
| Tufts Medical Center Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
| Atrium Health Levine Cancer Institute Coordinator of this site? Confirm its status | Charlotte | United States | Recruiting |
| The Ohio State University Comprehensive Cancer Center Coordinator of this site? Confirm its status | Columbus | United States | Recruiting |
| UT Southwestern, Harold C. Simmons Comprehensive Cancer Center Coordinator of this site? Confirm its status | Dallas | United States | Not yet recruiting |
| UNC Lineberger Comprehensive Cancer Center Coordinator of this site? Confirm its status | Durham | United States | Recruiting |
| Cedars-Sinai Medical Center Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
| Columbia University Irving Medical Center Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| Memorial Sloan-Kettering Cancer Center Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| VCU Medical Center Coordinator of this site? Confirm its status | Richmond | United States | Recruiting |
| University of Utah, Huntsman Cancer Hospital Coordinator of this site? Confirm its status | Salt Lake City | United States | Recruiting |
| University of California San Francisco Coordinator of this site? Confirm its status | San Francisco | United States | Recruiting |
| Cleveland Clinic Florida, Weston Hospital Coordinator of this site? Confirm its status | Weston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.