NCT06370845RecruitingEarly phase 1
ABUNDANCE of A NATURAL ODOUR in HUMAN CEREBROSPINAL FLUID AFTER OLFACTORY EXPOSURE - the OLFO-Brain Study
Source: ClinicalTrials.gov · Last updated 4 May 2026
Brief summary (registry, in English)
The goal of this clinical trial is to investigate the abundance of a natural odour in human cerebrospinal fluid in obese and lean participants after inhalation thereof. Participants will undergo blood sample collection and inhalation of either a natural odour or placebo through an inhaler in addition to a liquor puncture prescribed in standard of care context.
- Status (registry)
- Recruiting
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 32 (estimated)
- First submitted
- 21 Mar 2024
- Start date
- 14 Apr 2026
- Primary completion date
- 31 Aug 2027
- Lead sponsor
- University Hospital, Basel, Switzerland
- Diseases
- Obesity
- NCT number
- NCT06370845
What you commit to
- Study type: Interventional · Early phase 1
- Planned participants: 32
- From 14 Apr 2026 to the primary completion date, 31 Aug 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Present or past surgical intervention of the nasal cavity, the paranasal sinus, the pituitary or the frontal brain
Other illness
- Known allergy to the natural odour
- Acute upper respiratory tract infection, acute or chronic sinusitis
- Any kind of severe chronic disease (e.g. severe heart failure, active cancer disease, severe renal impairment with an estimated glomerular filtration rate \<30 ml/min/m2)
Other
- Pregnancy/lactation
- Inability to understand the study procedure and to sign the study consent
Who the study is looking for
- Age 18-60 years
- Written informed consent
- Scheduled for routine liquor puncture
- BMI ≥ 30 kg/m2
- No proven diagnose of diabetes
- Age 18-60 years
- Written informed consent
- Scheduled for routine liquor puncture
- BMI 18-25 kg/m2
Age in the registry: 18 years to 60 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital of Basel Coordinator of this site? Confirm its status | Basel | Switzerland | Recruiting |
| University Hospital Basel Coordinator of this site? Confirm its status | Basel | Switzerland | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.