NCT06372470Completed
Personalised Dose Optimisation of Zestril Supported by the Digital Blood Pressure Diary in a Primary Care Environment in England: Pragmatic Observational Pilot Study for Remote Hypertension Treatment
Source: ClinicalTrials.gov · Last updated 20 Mar 2026
Brief summary (registry, in English)
A pragmatic observational proof-of-concept study which aims to determine the feasibility of a remote titration clinic, assisted by home blood pressure monitoring and digital solutions, and assess its impact on real-world outcomes. By incorporating home blood pressure monitoring, the study seeks to offer a promising solution for personalised drug titration and self-management, potentially enhancing patient outcomes while optimising Zestril utilisation
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 20 (actual)
- First submitted
- 15 Apr 2024
- Start date
- 15 Apr 2024
- Primary completion date
- 31 Oct 2024
- Lead sponsor
- Closed Loop Medicine
- Diseases
- High blood pressure
- NCT number
- NCT06372470
What you commit to
- Study type: Observational
- Participants enrolled: 20
- From 15 Apr 2024 to the primary completion date, 31 Oct 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Clinically significant abnormal blood results as judged by the investigator (exclude patients with known renal impairment).
- History of clinically important medical conditions that would compromise a patient's ability to participate safely (including an allergic reaction to Zestril/lisinopril or any other medicine and/or other contraindications and interactions listed in Zestril's SmPC).
- Patients with a strongly activated renin-angiotensin-aldosterone system (in particular, renovascular hypertension, salt and /or volume depletion, cardiac decompensation, or severe hypertension) as per SmPC
- Any condition associated with poor compliance including alcoholism or drug dependence.
- Failure to satisfy the investigator of fitness to participate for any other reason.
Other
- Participants who are unwilling or unable to participate in remote study procedures, including home BP monitoring, remote consultations, and data submission as judged by the investigator.
- Participants with cognitive impairments or language barriers that hinder their ability to understand and comply with study instructions and e-questionnaires.
Who the study is looking for
- Adults aged 18 years and older.
- Patients diagnosed with uncomplicated essential (primary) hypertension eligible for Zestril per SmPC for hypertension management.
- Participants must provide written informed consent to participate in the study, including agreeing to adhere to the study procedures.
- Have access to and be able to use a suitable smartphone independently, running either iOS version 15 or later or Android version 10 or later.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Norwich Health Centre Coordinator of this site? Confirm its status | Norwich | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.