NCT06378619Terminated
Tapping Test and the Archimedean Spiral for the Differential Diagnosis of Tremor. Machine Learning Approach
Machine Learning Analysis Of The Tapping Test And The Archimedean Spiral For The Differential Diagnosis Of Essential Tremor And Parkinson's Disease.
Source: ClinicalTrials.gov · Last updated 28 Oct 2026
Brief summary (registry, in English)
In clinical practice, it is sometimes difficult to establish whether a patient's tremor is due to Parkinson's disease or essential tremor. The distinction is crucial as the health implications differ significantly between the two conditions. Therefore, the present study aims to develop a diagnostic method based on machine learning techniques to help differentiate whether a patient's tremor is due to one condition or the other. To achieve this, 110 patients with tremor, correctly diagnosed with either Parkinson's disease or essential tremor, will participate. They will undergo two diagnostic tests (tapping test and Archimedean spiral) to capture data that can be processed using machine learning techniques.
- Status (registry)
- Terminated
- Study type
- Observational
- Enrollment
- 11 (actual)
- First submitted
- 15 Apr 2024
- Start date
- 15 Jul 2024
- Primary completion date
- 1 Mar 2026
- Lead sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
- Diseases
- Parkinson disease
- NCT number
- NCT06378619
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients undergoing treatment with antipsychotics or antidepressants.
- Patients undergoing treatment with dopaminergic agonists or primidone.
- Participants diagnosed with any of the following conditions:
- Alcoholism of sufficient intensity to influence handwriting or cause neuropathy, at the investigator's discretion. Peripheral neuropathy of any cause. Dystonias. Previous stroke.
Other illness
- Patients with Parkinson's disease and dyskinesias.
Other
- Tremor of such severity that it prevents continuous tracing, at the investigator's discretion.
- Cognitive or affective pathology that limits the ability to collaborate with the study procedures.
- Participation in another clinical study involving an intervention, procedure, or visit frequency that is incompatible with the present study.
Who the study is looking for
- Possibility to collaborate in the necessary evaluations.
- Follow-up in the specialized consultation of Movement Disorders at the Neurology Service of Hospital Sant Camil-Consorci Sanitari Alt Penedes i Garraf.
- Legal capacity to provide informed consent.
- Signature of informed consent for study inclusion, either by the participant themselves or by their legal representative.
- Participant with criteria from Group 1 or 2:
- Group 1:
- Confirmed diagnosis of tremor due to Parkinson's disease, clinically established, based on the diagnostic criteria of the Movement Disorders Society, and additionally:
- Tremor associated with bradykinesia of any duration.
- Confirmatory clinical diagnosis of tremor due to Parkinson's disease (stages 1 to 2 of Hoehn and Yahr) by the neurologist responsible for the participant's follow-up.
- Group 2:
- Confirmed diagnosis of essential tremor, based on the criteria of the Movement Disorders Society, and additionally:
- Positional tremor plus kinetic and/or resting tremor with follow-up in outpatient neurology consultations for at least 3 years without a change in diagnosis.
- Absence of bradykinesia.
Age in the registry: 45 years to 79 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Sant Camil-Consorci Sanitari Alt'Pènedes i Garraf Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.