NCT06381648Completed
Detecting Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma (LyMIC)
An Exosome-based Liquid Biopsy Signature for Pre-operative Identification of Lymph Node Metastasis in Patients With Intrahepatic Cholangiocarcinoma
Source: ClinicalTrials.gov · Last updated 13 Mar 2026
Brief summary (registry, in English)
Lymph node metastasis (LNM) is a major prognostic factor in intrahepatic cholangiocarcinoma (ICC), and accurate preoperative prediction of the presence or absence of LNM has significant clinical implications in determining treatment strategy. Despite this, there are currently no reliable biomarkers established to detect LNM in ICC. This study seeks to develop a liquid biopsy assay that can accurately detect LNM before treatment in ICC patients.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 230 (actual)
- First submitted
- 19 Apr 2024
- Start date
- 15 Apr 2023
- Primary completion date
- 1 Jun 2025
- Lead sponsor
- City of Hope Medical Center
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT06381648
What you commit to
- Study type: Observational
- Participants enrolled: 230
- From 15 Apr 2023 to the primary completion date, 1 Jun 2025
- 4 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Synchronous Intrahepatic cholangiocarcinoma and non- Intrahepatic cholangiocarcinoma diagnosed at or before surgery
Other illness
- Secondary liver cancer
Other
- Lack of or inability to provide informed consent
Who the study is looking for
- A histologically confirmed diagnosis of intrahepatic cholangiocarcinoma.
- Received standard diagnostic and staging procedures as per local guidelines
- Availability of at least one blood-derived sample, drawn before receiving any curative-intent treatment
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University Coordinator of this site? Confirm its status | Fukuoka | Japan | Unknown status |
| Department of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University Coordinator of this site? Confirm its status | Hokkaido | Japan | Unknown status |
| Department of Surgery, Tokushima University Coordinator of this site? Confirm its status | Tokushima | Japan | Unknown status |
| City of Hope Medical Center Coordinator of this site? Confirm its status | Duarte | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.