NCT06385496Active, not recruitingPhase 2

Testing MLN0128 (TAK-228) as Potentially Targeted Treatment in Cancers With mTOR Genetic Changes (MATCH - Subprotocol L)

MATCH Treatment Subprotocol L: Phase II Study of MLN0128 (TAK-228) in Patients With Tumors Wtih mTOR Mutations

Source: ClinicalTrials.gov · Last updated 3 Nov 2026

Brief summary (registry, in English)

This phase II MATCH treatment trial tests how well MLN0128 (TAK-228) works in treating patients with cancer that has certain genetic changes called mTOR mutations. MLN0128 (TAK-228) may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

Status (registry): Active, not recruiting
Phase (registry): Phase 2
Study type: Interventional
Enrollment: 35 (estimated)
First submitted: 25 Apr 2024
Start date: 12 Mar 2017
Primary completion date: 31 Dec 2026
Lead sponsor: National Cancer Institute (NCI)
Diseases: Multiple myeloma
NCT number: NCT06385496

What you commit to

Study type: Interventional · Phase 2
Planned participants: 35
From 12 Mar 2017 to the primary completion date, 31 Dec 2026
1 site in 1 country
Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Who the study is looking for

Patients must have met applicable eligibility criteria in the Master MATCH Protocol EAY131/ NCI-2015-00054 prior to registration to treatment subprotocol
Patients must fulfill all eligibility criteria of MATCH Master Protocol at the time of registration to treatment step (Step 1, 3, 5, 7)
Patients must have a mutation in mTOR, KEAP1 or NFE2L2 as determined via the MATCH Master Protocol
Patients must have an electrocardiogram (ECG) within 8 weeks prior to treatment assignment and must NOT have any of the following cardiac criteria:
- Clinically important abnormalities in rhythm, conduction or morphology of resting ECG (e.g. complete left bundle branch block, third degree heart block, Corrected QT Interval \[QTc\] interval \> 480 milliseconds)
- Uncontrolled hypertension (i.e., systolic blood pressure \>180 mm Hg, diastolic blood pressure \> 95 mm Hg). Use of anti-hypertensive agents to control hypertension before cycle 1, day 1 is allowed
- Known pulmonary hypertension.
Patients must not have known hypersensitivity to MLN0128 or compounds of similar chemical or biologic composition
Patients must not have known hepatitis B surface antigen-positive, or known or suspected active hepatitis C infection, but may have had previously treated and successfully eradicated hepatitis C virus (HCV)
Patients must have none of the following within six months of receiving the first dose of MLN0128 (TAK-228): ischemic, myocardial or cerebrovascular event, class III or IV heart failure, placement of pacemaker, or pulmonary embolism
Patients must have no manifestations of malabsorption due to prior gastrointestinal (GI) surgery, GI disease, or for an unknown reason that may alter the absorption of MLN0128 (TAK-228)
Patients who have a history of brain metastasis are eligible for the study provided that all the following criteria are met:
- Brain metastases which have been treated
- No evidence of disease progression for \>= 1 months before the first dose of study drug
- No hemorrhage after treatment
- Off-treatment with dexamethasone for 4 weeks before administration of the first dose of MLN0128 (TAK-228)
No ongoing requirement for dexamethasone or anti-epileptic drugs
Patients meeting the following criteria for concomitant medications prior to starting MLN0128 (TAK-228) are not eligible for the study:
- Patients who use a proton pump inhibitor (PPI) within 7 days before receiving the first dose of study drug.
- Patients who would require treatment with PPIs throughout the trial
- Patients who would need to take H2 receptor antagonists within 24 hours of the first dose of study drug NOTE Strong CYP1A2 inhibitors and CYP inducers should be administered with caution, at the discretion of the investigator. Alternative treatments, if available, should be considered
Patients must not have known treatment with systemic corticosteroid within one week prior to the first administration of study drug
Patients must not have uncontrolled diabetes mellitus. Controlled diabetes is defined as: Glycosylated hemoglobin (HbA1c) \< 7.0%, or fasting serum glucose (=\< 130 mg/dL)
Patients must not have fasting triglycerides \>= 300 mg/dL
Patients must not have had prior treatment with other known TORC1/2 inhibitors, including:
- AZD8055
- XL765
- BEZ235
- GSK2126458
- XL388
- DS3078(a)
- PF-05212384
- SF1126
- Palomid-529
- GDC0980 (apitolisib)
- LY30223414
- BKM120
- OSI0127
- MLN0128 (TAK-228)
- AZD2014
Patients must not have other clinically significant co-morbidities that, in the opinion of the investigator, would limit compliance with study requirements
Fertility and developmental studies with MLN0128 (TAK-228) have not been conducted. On the basis of potential hazard of other mTOR inhibitors (i.e., rapamycin and other rapalogs) on the developing fetus, women of childbearing age should avoid becoming pregnant while taking MLN0128 (TAK-228). For this reason, women of child-bearing potential and men must agree to practice 1 highly effective method of contraception and 1 additional effective (barrier) method of contraception, at the same time, from the time of signing the informed consent through 120 days after the last dose of study drug, or agree to completely abstain from heterosexual intercourse. Men must agree not to donate sperm during the course of this study or within 120 days after receiving their last dose of study drug
Patients who are known to be HIV-positive are not eligible for this study

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

Site	City	Country	Site status
ECOG-ACRIN Cancer Research Group Coordinator of this site? Confirm its status	Philadelphia	United States	Unknown status

This page is information, not medical advice. Discuss any trial with your doctor.