NCT06386588Recruiting
The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia
The Effects of Auditory Stimulation During Sleep on Offline Learning and Thalamocortical-hippocampal Connectivity in Schizophrenia
Source: ClinicalTrials.gov · Last updated 20 Oct 2026
Brief summary (registry, in English)
In this research study the investigators will use sleep headbands to measure brain rhythms and to improve their coordination across brain regions. The headbands will be worn at home for multiple nights. On some nights the headbands will play soft sounds at specific times during sleep. The investigators are interested in learning whether this timed auditory stimulation may be a strategy to improve the coordination of sleep rhythms across brain regions, improve network communication, and as a result, improve memory. The investigators will study 30 adults aged 18-45 with schizophrenia and 30 demographically matched healthy controls. Participants will first have a daytime MRI scan, during which they will complete a finger tapping motor sequence task (MST), followed by a week of sleep at home with a sleep headband. They will also do the MST at home on two of the nights. On the final day of the study, participants will return for a second MRI scan.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 28 Mar 2024
- Start date
- 5 Feb 2025
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- Massachusetts General Hospital
- Diseases
- Schizophrenia
- NCT number
- NCT06386588
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 5 Feb 2025 to the primary completion date, 30 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current use of psychotropic medications or treatment with medications known to affect sleep or cognition
Other illness
- Other neurological disorders, including seizure disorder
- Chronic medical conditions that affect sleep
- Unstable chronic medical condition such as asthma, diabetes, cystic fibrosis, or cardiac disease
- Diagnosed sleep disorder, except insomnia
- History of head injury resulting in prolonged loss of consciousness or other neurological sequelae
- Additional Exclusion Criteria for Healthy adults:
- History of mental illness
Other
- Ferrous metal in the body
- Currently pregnant or breastfeeding
- Motor problems that preclude finger tapping task
- IQ \<85
- Significant hearing or vision loss
Who the study is looking for
- 18-45 years old
- Fluent in English
- Able to give informed consent
- Additional inclusion for Adults with schizophrenia:
- A DSM-V confirmed diagnosis of schizophrenia
- Unmedicated or maintained on a stable dose of APDs
Age in the registry: 18 years to 45 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Charlestown | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.