NCT06387784Not yet recruiting
Acute Beetroot Juice Supplementation in Pre-eclampsia Pregnancies
Acute Effect of Beetroot Juice Supplementation in Pregnant Women With Pre-eclampsia: a Single-Blind Randomized Placebo-Controlled Trial
Source: ClinicalTrials.gov · Last updated 21 Apr 2026
Brief summary (registry, in English)
Pre-eclampsia is a serious condition that typically affects pregnant women after the 20th week of pregnancy, characterized by high blood pressure and damage to organs such as the kidneys and liver. Currently, treatment options are limited, which has prompted researchers to explore alternative approaches. One such promising alternative is dietary nitrate found in vegetables like beetroot, as nitrate can be converted into nitric oxide in the body, which helps lower blood pressure. This study aims to determine the acute effects of nitrate-rich beetroot juice on blood pressure, several blood and salivary markers in pregnant women with pre-eclampsia and healthy pregnant. Furthermore, the study will assess fetal blood flow using Doppler ultrasound. We want to understand the kinetics of nitrate and nitric oxide metabolites and assess the temporal dependency of the hypotensive response. Through this investigation, we seek evidence of nitrate-enriched beetroot juice as an adjunct therapy in managing pre-eclampsia.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 16 Apr 2024
- Start date
- 18 May 2026
- Primary completion date
- May 2027
- Lead sponsor
- University of Sao Paulo
- NCT number
- NCT06387784
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 18 May 2026 to the primary completion date, May 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Medications such as non-steroidal anti-inflammatory drugs, nasal decongestants, users of proton pump inhibitors and H2 receptor antagonists or any other medication that interferes with stomach pH.
Other illness
- Uncontrolled arterial hypertension (Systolic Blood Pressure \> 160 mmHg or Diastolic Blood Pressure \> 100 mmHg).
- History of food allergy with hypersensitivity to beetroot.
- Diagnosis of renal or hepatic disease affecting nitrate metabolism.
- Cardiac conditions such as moderate to severe congestive heart failure and coronary artery disease.
- Pre-existing type 1 or type 2 diabetes.
Other
- Multiple pregnancies.
- Pregnant women with a body mass index \> 40 kg/m²
- Severe gestational complications.
- Smokers.
- Chronic alcohol consumption.
- Healthy Pregnant Women
- \- The same exclusion criteria from Pre-eclampsia group apply.
Who the study is looking for
- Pregnant women at or beyond the 20th week of gestation.
- Hospitalized at Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto.
- Diagnosed with early-onset pre-eclampsia confirmed by a medical professional.
- Capacity to provide written informed consent for study participation.
- Healthy pregnant women at or beyond the 20th week of gestation.
- Absence of pre-eclampsia diagnosis or other obstetric complications.
- Willingness and ability to remain admitted at the Clinical Research Unit for the - period required by the study.
- Capacity to provide written informed consent for study participation.
Criteria the registry did not label
- Pre-eclampsia pregnat women
Age in the registry: 18 years to 40 years · Sex: Female · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital das Clínicas de Ribeirão Preto Coordinator of this site? Confirm its status | Ribeirão Preto | Brazil | Unknown status |
| Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP Coordinator of this site? Confirm its status | Ribeirão Preto | Brazil | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.