NCT06390345Recruiting
Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention
Source: ClinicalTrials.gov · Last updated 22 Jul 2026
Brief summary (registry, in English)
The investigators will conduct a Type I hybrid effectiveness-implementation study to test an integrated telehealth intervention among 400 overweight and obese patients with Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA). The investigators will include eligible participants receiving primary care at one of five Department of Veterans Affairs (VA) medical centers and their community-based outpatient clinics. The investigators will randomize patients in a 1:1 ratio to the multi-component intervention or "enhanced" usual care, stratifying by age (≥65 vs. \< 65) and site. Participants randomized to the intervention will receive an integrated, telehealth-delivered intervention composed of a self-directed lifestyle program and supervised pulmonary rehabilitation. At the end of 3 months, the investigators will offer to enter a recommendation for weight management medications on behalf of eligible intervention participants. In the post-core period (months 4-12), participants will continue to have as-needed access to the lifestyle coach. For participants randomized to the "enhanced" usual care group, study staff will prompt the patient's primary care provider to refer them to existing weight loss management and pulmonary rehabilitation programs. Follow-up will occur at virtual visits at 3 and 12 months. The primary effectiveness outcome at 1-year is quality of life measured by the SF-12 Physical Component Summary Score. Secondary effectiveness outcomes will include other measures of quality of life (including sleep related impairment), sleep disturbance, disease severity (COPD exacerbations and respiratory event index for OSA), depression, social support, weight loss and cardiovascular risk. In addition to assessing effectiveness, investigators will also conduct a concurrent implementation process evaluation using the RE-AIM framework.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 400 (estimated)
- First submitted
- 25 Apr 2024
- Start date
- 29 Jul 2024
- Primary completion date
- 1 Jul 2028
- Lead sponsor
- Seattle Institute for Biomedical and Clinical Research
- NCT number
- NCT06390345
What you commit to
- Study type: Interventional
- Planned participants: 400
- From 29 Jul 2024 to the primary completion date, 1 Jul 2028
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Self-report of weight change \>15 lbs. during prior 3 months
- Current active weight loss treatment, including: 1) research-based commercial weight loss programs (e.g., Weight Watchers, Jenny Craig, HMR, Omada, TOPS, MOVE!); 2) other weight loss or related behavioral health or wellness programs led by trained personnel (professional or lay) in the local community; 3) prescription weight loss medication within last 3 months; and scheduled bariatric surgery.
Other illness
- Severe illness from any cause
- Diagnosis of bulimia or history of purging behavior
- Safety and/or adherence concerns due to severe physical or mental health issues or life expectancy \< 12 months. These include but may not be limited to: unstable cardiac arrhythmias, active or recent (within one month) myocardial infarction, active or recent (within one month) COPD exacerbation, angina not well-controlled with medication, significant musculoskeletal comorbidities or physical infirmities that preclude participation in an exercise program, and the need for supplemental oxygen ≥ 5 lpm at rest or with exertion.
Other
- Active enrollment in pulmonary rehabilitation
- Pregnant, lactating, or planning to become pregnant during the study period
- Participation in other intervention studies.
- Prisoner
- Unable to complete surveys in English
Who the study is looking for
- COPD: Defined by presence of airflow obstruction (FEV1/FVC \< 0.70) on post-bronchodilator spirometry
- ≥10 pack year history of tobacco use
- Self-reported clinician diagnosis of OSA (or presence of OSA on research HSAT)
- BMI ≥ 25 kg/m2
- Symptoms of dyspnea defined by MMRC score of ≥1
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Boise VA Medical Center Coordinator of this site? Confirm its status | Boise | United States | Recruiting |
| Jesse Brown VA Medical Center Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| Minneapolis VA Health Care System Coordinator of this site? Confirm its status | Minneapolis | United States | Recruiting |
| VA Puget Sound Health Care System Coordinator of this site? Confirm its status | Seattle | United States | Recruiting |
| Mann-Grandstaff VA Medical Center Coordinator of this site? Confirm its status | Spokane | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.