NCT06390579Completed
Building Research With Artificial Intelligence in Neuro-Ophthalmology
Source: ClinicalTrials.gov · Last updated 8 Sept 2025
Brief summary (registry, in English)
The research team, recognized as a world leader in Artificial Intelligence for neuro-ophthalmology, has shown that it is possible to diagnose certain neuro-ophthalmologic or neurologic disorders from a single retinal fundus image (Milea et al, New England Journal of Medicine, 2020). However, clinical practice requires identifying a broader spectrum of diseases (inflammatory, ischemic, hereditary, neurodegenerative) within the same analysis. The main objective is to develop, through a new algorithm capable of classifying multiple disorders from a smaller set of conventional retinal images. This project meets a significant public health need: the global shortage of neuro-ophthalmologists. It aims to provide healthcare professionals with a rapid triage tool to detect serious and treatable conditions, enabling timely intervention. The study will include patients with clearly defined neuro-ophthalmologic or neurologic conditions, confirmed diagnoses, and retinal imaging. Clinical, paraclinical, and imaging data collected during standard care will be used, with strict anonymization according to legal and institutional requirements. Specific Objectives : 1. Evaluate the performance of a diagnostic classification algorithm trained on retinal images. 2. Assess the ability to detect multiple pathologies from a single retinal image. 3. Support the development of advanced computer vision tools for medical diagnostics.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 693 (actual)
- First submitted
- 25 Apr 2024
- Start date
- 1 Oct 2023
- Primary completion date
- 1 Feb 2024
- Lead sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
- Diseases
- Childhood cancers
- NCT number
- NCT06390579
What you commit to
- Study type: Observational
- Participants enrolled: 693
- From 1 Oct 2023 to the primary completion date, 1 Feb 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Patients without a confirmed diagnosis or unclear clinical classification.
- Patients without retinal fundus images or with images that are completely unreadable.
- Patients whose data cannot be anonymized according to legal and institutional protocols.
Who the study is looking for
- Patients with well-defined neuro-ophthalmologic or neurologic conditions, including different forms of optic neuropathies and various neurodegenerative diseases.
- Patients with a robust reference diagnosis confirmed by clinical experts.
- Patients with available retinal fundus images collected during routine care.
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hopital Fondation Adolphe de Rothschild Coordinator of this site? Confirm its status | Paris | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.