NCT06390930Recruiting
Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS
Investigating the Effects of Acute Intermittent Hypoxia on Neuroplasticity in Persons With Multiple Sclerosis
Source: ClinicalTrials.gov · Last updated 23 Feb 2026
Brief summary (registry, in English)
This study seeks to explore changes in the neural pathways and arm function following a breathing intervention in the multiple sclerosis (MS) population. The breathing intervention, known as Acute Intermittent Hypoxia (AIH), involves breathing brief bouts of low levels of oxygen. Research has found AIH to be a safe and effective intervention resulting in increased ankle strength in people with MS. Here, the study examines arm and hand function before and after AIH. In order to better understand the brain and spinal cord response to AIH, the investigators will measure muscle response, and signals sent from the brain to the arm muscles before and after AIH.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 22 (estimated)
- First submitted
- 24 Apr 2024
- Start date
- 1 Feb 2025
- Primary completion date
- Jul 2026
- Lead sponsor
- Shirley Ryan AbilityLab
- Diseases
- Multiple sclerosis
- NCT number
- NCT06390930
What you commit to
- Study type: Interventional
- Planned participants: 22
- From 1 Feb 2025 to the primary completion date, Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Uncontrolled hypertension or hypotension (outside 140/90 and 85/55 mmHg)
- History of epilepsy, chronic obstructive pulmonary disease, or sleep apnea
- Unstable medical conditions, ongoing upper limb therapy, or musculoskeletal pain
Other
- Another diagnosis (e.g., peripheral neuropathies or orthopedic) affecting upper limb function
- Mini-Mental State Examination (MMSE) score \<24
- Modified Ashworth Scale score \>3 on elbow joint
- Pregnancy as confirmed by urine test
Who the study is looking for
- Diagnosis of relapsing-remitting MS according to the McDonald criteria, over 5 years ago
- Relapse free for at least 6 months
- Expanded Disability Status Scale (EDSS) ≤7
- Index finger abduction strength \<5 according to Medical Research Council Scale, or 9-Hole Peg Test score \>20 seconds in at least one hand
- Stable disease modifying therapies for at least 6 months
- Individuals taking dalfampridine will be eligible if taking the same daily dose for at least 2 months prior to screening
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shirley Ryan AbilityLab Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.