NCT06391086Recruiting
Neuromodulation Effect of Focused Ultrasound for Motor Recovery in Patients With Stroke
Source: ClinicalTrials.gov · Last updated 13 Apr 2026
Brief summary (registry, in English)
Transcranial focused ultrasound (tFUS) can be used as a non-invasive brain neuromodulation technique. Low-intensity focused ultrasound has been demonstrated to be safe and have neuromodulatory effects on the cerebral cortex in healthy human and animal experiments.This study aims to investigate the effect of tFUS on cortical excitability for motor recovery in patients with stroke.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 25 Apr 2024
- Start date
- 1 Aug 2024
- Primary completion date
- 1 Oct 2029
- Lead sponsor
- National Taiwan University Hospital
- Diseases
- Stroke
- NCT number
- NCT06391086
What you commit to
- Study type: Interventional
- Planned participants: 50
- From 1 Aug 2024 to the primary completion date, 1 Oct 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with metallic implants in their bodies;
- Patients taking tricyclic antidepressants, analgesics, or using antiepileptic drugs
Other illness
- History of recurrent stroke, traumatic brain injuries, brain tumors, spinal cord injury, Parkinson's disease or other musculoskeletal system diseases that may affect evaluation and treatment.
- Major physical illnesses and neurological disorders (such as epilepsy, brain surgery, etc.)
- Individuals experiencing sleep disorders during tFUS treatment;
- Individuals with history of alcoholism
Lab values
- Contraindications to focused ultrasound, including pregnancy, cardiac pacemaker or implantable medical device, abnormal connective tissue diseases, coagulopathy (PLT\<100,000/μL, PT\>14 seconds, APTT\>36 seconds, INR\>1.3), implants near or in the brain, or those deemed Unsuitable for this treatment by the physician.
- Patient under anticoagulants with coagulopathy (PLT\<100,000/μL, PT\>14 seconds, APTT\>36 seconds, INR\>1.3)
Other
- Unable to cooperate with treatment or functional assessment due to impaired consciousness or aphasia; inability to informed consent.
- Patient with cranial bone factor causing the inability of tFUS penetration.
- Patients who are not suitable for undergoing CT imaging examination;
- Patients with severe or uncontrollable intracranial pressure;
- Patients requiring anticoagulants;
- Any intracranial space-occupying lesions;
- Significant calcification of intracranial vessels based on pre-treatment CT imaging;
- Subjects with lesions/wounds on the scalp in the target region.
Who the study is looking for
- Patients with stroke (including hemorrhagic or ischemic stroke) diagnosed by a board-certificated physician.
- Occurrence of stroke within three months.
- Upper limb muscle strength ≤ 4 points according to the Medical Research Council Manual Muscle Testing scale.
- No previous history of stroke, epilepsy, dementia, Parkinson's disease, or other neurodegenerative diseases.
- Patients could maintain sitting posture for more than 15 minutes on a chair.
- 18 years of age or older.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| National Taiwan University Hospital Coordinator of this site? Confirm its status | Taipei | Taiwan | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.