NCT06391684Recruiting
Flexibility and the Predictive Brain in Autistic Males and Females
Neurofunctional Specificities in Predictive Processing During High-Level Cognitive Flexibility Tasks in Autistic Males and Females
Source: ClinicalTrials.gov · Last updated 2 Oct 2026
Brief summary (registry, in English)
The goal of this study is to compare the neural correlates of predictive brain mechanisms during high-level social and non-social flexibility tasks, between autistic and non-autistic males and females. The aim is to better understand if autistic individuals differ from non-autistic individuals in their cognitive flexibility according to the social and predictable nature of the stimuli, at a behavioral and neurofunctional level using the functional Magnetic Resonance Imaging (fMRI). As autistic females usually present a more subtle profile than autistic males, the investigators will also explore if autistic males and females present neurofunctional differences.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 40 (estimated)
- First submitted
- 8 Feb 2024
- Start date
- 21 Feb 2025
- Primary completion date
- 20 Apr 2029
- Lead sponsor
- University Hospital, Grenoble
- Diseases
- Autism
- NCT number
- NCT06391684
What you commit to
- Study type: Observational
- Planned participants: 40
- From 21 Feb 2025 to the primary completion date, 20 Apr 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any subject with a vascular stent implanted less than 6 weeks before the examination.
Other illness
- Any acquisition procedure not meeting the conditions required for "conditional" use in subjects with implanted biomedical material classified as "conditional" in the list: http://www.mrisafety.com/TheList\_search.asp.
- Any subject with biomedical material such as a cardiac, neuronal, or sensory stimulator (cochlear implant due to the risk of demagnetization, heating, electrode, and artifacts) or a ventricular shunt valve without medical and paramedical supervision trained in MRI performance in these subjects.
- Claustrophobia - Psychiatric or neurological conditions other than those specified.
- Existence of a severe general health condition incompatible with the study: cardiac, respiratory, hematological, renal, hepatic, or cancerous.
Other
- Any subject with implanted biomedical material deemed "unsafe" or "not safe" in the list: http://www.mrisafety.com/TheList\_search.asp.
- Intraocular or intracranial ferromagnetic foreign body near nerve structures (risk of displacement and complications such as ocular or cerebral lesions).
- Alcohol ingestion before the examination.
- Persons covered by articles L1121-5 to L1121-8 of the Public Health Code (pregnant or breastfeeding women, minors or adults under legal protection, individuals under administrative or judicial surveillance).
- Visual impairments.
- Intellectual disability.
- Inability to understand research instructions or provide informed consent.
Who the study is looking for
- For non autistic individuals
- Affiliation with social security scheme.
- Registration in the national database of individuals willing to participate in research involving human subjects.
- Absence of contraindications for MRI.
- Signed informed consent before any study-related procedure.
- Visual acuity allowing normal perception of stimuli or corrected vision.
- Autism Quotient (AQ) (Baron-Cohen et al., 2001) \< 32.
- For autistic individuals:
- Affiliation with social security scheme.
- Absence of contraindications for MRI.
- Signed informed consent before any study-related procedure.
- Visual acuity allowing normal perception of stimuli or corrected vision.
- Diagnosis of autism established by a competent professional based on DSM/ICD criteria.
Age in the registry: 18 years to 50 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU Grenoble Alpes_DRCI_Pavillon Dauphiné_CS Coordinator of this site? Confirm its status | Grenoble | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.