PCSK9 Inhibitors in Combination With Advanced Treatment Strategies for the Treatment of Advanced Colorectal Cancer With pMMR/MSS

Prior treatment

• Hypocholesterolemia, hypolipidemia and its family history, previous allergic reaction to PCSK9 inhibitors History of allergic reaction to PCSK9 inhibitors;
• preoperative pathological diagnosis of advanced colorectal adenocarcinoma without pMMR/MSS, with the chance of radical surgical treatment;
• Hypolipidemia caused by combination with other long-term lipid-lowering drugs;
• malignancies other than colorectal cancer with negligible risk of metastasis or death (e.g., expected 5-year OS \>90%) within 5 years prior to enrollment and for which a radical outcome is expected after treatment (e.g., adequately treated carcinoma in situ of the uterine cervix, basal or squamous cell skin cancers, limited prostate cancers treated for radical purposes, ductal carcinomas in situ treated for radical purposes surgically), with the exception of (b) the following;
• major surgery within 4 weeks prior to enrollment or incomplete recovery from previous surgery;
• systemic immunostimulatory drug therapy (including but not limited to interferon or IL-2) within 4 weeks or 5 half-lives of the drug, whichever is shorter, prior to enrollment;
• receipt of systemic corticosteroids (\>10 mg/d prednisone equivalent) or other systemic immunosuppressants, etc. within 2 weeks prior to randomization;
• previous allogeneic bone marrow transplantation or previous solid organ transplantation;
• history of idiopathic pulmonary fibrosis, drug-induced pneumonia, organic pneumonia (i.e., occlusive bronchiolitis), idiopathic pneumonia, or evidence of active pneumonia on CT scan of the chest at the time of screening; 13. receipt of any live vaccine (e.g., vaccines against infectious diseases such as influenza vaccine, varicella vaccine, etc.) within 4 weeks (28 days) prior to randomization
  • 14\. Pregnant or lactating female patients;
  • 15\. Hypersensitivity to fluorouracil-based or platinum-based agents or their excipients.

Other illness

• history of autoimmune diseases, including but not limited to myasthenia gravis, myositis, autoimmune hepatitis;
• pre-existing or clinically significant CNS disease at screening, such as epilepsy, seizures, paralysis, aphasia, stroke, severe brain injury, dementia, Parkinson's disease, cerebellar disease, organic brain syndromes, or psychiatric disorders;
• subjects who, in the judgment of the Investigator, have any factors affecting compliance with the protocol, including uncontrollable medical, psychological, familial, sociological, or geographic conditions; or who are unwilling or unable to comply with the procedures required in the study protocol;

• Age 18-75 years old, gender is not limited, and signed informed consent;
• Histologically confirmed colorectal adenocarcinoma with pMMR/MSS;
• Colorectal cancer with distant metastasis or inability to be radically surgically resected as assessed by imaging examination Patient;
• Immunohistochemistry or sequencing to evaluate the high expression status of PCSK9 in tumors;
• ECOG score 0-1;
• Expected survival ≥ 3 months.