NCT06392776Recruiting
Early Diagnosis and Treatment of Undiagnosed Asthma or COPD: THE UCAP 2 TRIAL
Source: ClinicalTrials.gov · Last updated 23 Sept 2026
Brief summary (registry, in English)
Our research group has found that Canadians with undiagnosed asthma or chronic obstructive pulmonary disease (COPD) have increased respiratory symptoms and worse health-related quality of life. The investigators recently developed and validated an on-line questionnaire to accurately identify these symptomatic, undiagnosed individuals. The investigators will advertise in the community asking individuals to complete the on-line questionnaire at home, at their leisure, to determine if they are at risk of asthma or COPD. Those at risk will be invited to participate in a randomized, controlled clinical trial to determine whether early diagnosis of previously undiagnosed asthma or COPD and subsequent treatment by the primary care practitioner will improve their quality of life.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 420 (estimated)
- First submitted
- 26 Apr 2024
- Start date
- 16 Jul 2024
- Primary completion date
- Dec 2028
- Lead sponsor
- Ottawa Hospital Research Institute
- NCT number
- NCT06392776
What you commit to
- Study type: Interventional
- Planned participants: 420
- From 16 Jul 2024 to the primary completion date, Dec 2028
- 6 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Individuals who report a previous diagnosis of asthma, COPD, history of lung cancer, bronchiectasis, interstitial lung disease, cystic fibrosis or other significant diagnosed lung disease.
- Individuals currently using inhaled corticosteroids or long-acting bronchodilators.
Other illness
- Individuals with history of myocardial infarction, stroke, aortic or cerebral aneurysm, or detached retina or eye surgery within the past 3 months (spirometry is contraindicated)
Other
- Individuals currently under the care of a Respirologist.
- Individuals who are in the third trimester of pregnancy
- Individuals involved in another interventional trial
Who the study is looking for
- Individuals at least 18 years old
- Individuals must be symptomatic with respiratory symptoms
- Individuals must complete the UCAP-Q questionnaire and score a ≥ 6% probability of having either asthma or COPD.
- Individuals who have given written informed consent to participate in this trial in accordance with local regulations;
- Individual must be able to perform pre and post bronchodilator spirometry to measure lung function
- Additional Inclusion Criteria for the Randomized Controlled Trial (RCT):
- Individuals who have undiagnosed airflow obstruction on spirometry testing (i.e. Asthma or COPD) will be asked to participate in the RCT.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (6)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| St. Joseph's Hamilton Healthcare Coordinator of this site? Confirm its status | Hamilton | Canada | Recruiting |
| Kingston Health Sciences Centre, Queen's University Coordinator of this site? Confirm its status | Kingston | Canada | Recruiting |
| Ottawa Hospital - General Campus Coordinator of this site? Confirm its status | Ottawa | Canada | Recruiting |
| Institut universitaire de cardiologie et de pneumologie de Québec Coordinator of this site? Confirm its status | Québec | Canada | Recruiting |
| Royal University Hospital Coordinator of this site? Confirm its status | Saskatoon | Canada | Recruiting |
| St. Michael's Hospital, Unity Health Toronto Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.