NCT06394180Recruiting
PeRforation EVents During ENdovascular Therapy for Acute Ischemic Stroke
PeRforation EVents During ENdovascular Therapy for Acute Ischemic Stroke (PREVENT) - Registry
Source: ClinicalTrials.gov · Last updated 9 Mar 2026
Brief summary (registry, in English)
A large, worldwide study called PREVENT is looking at a complication that can happen during a stroke treatment called thrombectomy. This complication is a perforation of a blood vessel. The investigators aim to: 1. Find what factors make this perforation more likely. 2. Understand why the perforation happens by looking closely at images taken during the procedure. 3. Create a simple way to classify these perforations to help doctors decide how to treat them right away. 4. Improve the emergent treatment of vessel perforation to stop the bleeding rapidly. 5. Provide data to guide decision whether thrombectomy should be continued or aborted after the event of vessel perforation. 6. Develop a safer way to perform thrombectomy. Investigators will compare the results collected for patients where perforation happened with those where perforation did not happen.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 1000 (estimated)
- First submitted
- 26 Apr 2024
- Start date
- 2 Dec 2024
- Primary completion date
- Dec 2026
- Lead sponsor
- University Hospital, Basel, Switzerland
- Diseases
- Stroke
- NCT number
- NCT06394180
What you commit to
- Study type: Observational
- Planned participants: 1000
- From 2 Dec 2024 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Presence of both ischemic stroke and intracranial hemorrhage on pre-interventional imaging.
- Patients with contrast medium extravasation into a venous space instead of free contrast medium extravasation, e.g. the cavernous sinus with consecutive development of a carotid-cavernous fistula.
Other
- Presence of a documented rejection
- Patients with intracranial dissection without active contrast extravasation.
- Patients with rupture of a pre-existing intracranial aneurysm during thrombectomy.
Who the study is looking for
- Age ≥ 18 years at time of thrombectomy
- Acute ischemic stroke with occlusion of one or several intracranial arteries and subsequent thrombectomy.
- Target cohort: Occurrence of intracranial perforation during thrombectomy with evidence of contrast extravasation in at least one diagnostic angiography series.
- Comparison cohort: No perforation during thrombectomy. Every patient in the comparison group is matched to one patient in the target population. Matching will be carried out with respect to age, gender, participating center and location of the vascular occlusion.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital Basel Coordinator of this site? Confirm its status | Basel | Switzerland | Recruiting |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.