NCT06396611Active, not recruiting
Exercise As Intervention in Chronic Lymphocytic Leukemia
Randomised Controlled Clinical Trial of Exercise As Intervention in Chronic Lymphocytic Leukemia
Source: ClinicalTrials.gov · Last updated 19 Mar 2025
Brief summary (registry, in English)
PURPOSE: The purpose of the study is to determine the effects of 16-weeks of exercise training, as measured by aerobic capacity, strength and physical function, and body composition, in patients with Chronic Lymphocytic Leukemia (CLL). DESIGN: Subjects will have confirmed treatment naïve CLL. Subjects will be assigned to either a 16-week control group (no supervised exercise) or an intervention group of Resistance Training (REx). Before and after the 16-week protocol, patients will undergo several tests including: 1) a maximal cycle ergometer test, 2) Body Composition, 3) Muscle strength, 4) physical activity levels, 5) blood measures (e.g. immune and inflammatory functions). DATA ANALYSES \& SAFETY ISSUES: For outcomes, group change differences from baseline to 16-weeks will be compared with ANCOVA. Resistance training is a very safe exercise modality already studied in other cancer patients. The regular use of vigorous-intensity exercise has been used extensively in exercise training. It will always be respected for each subject's safety tolerance while challenging. HYPOTHESIS: The investigators hypothesize that the protocol will be feasible exercise interventions for people with CLL and will improve health and fitness markers.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 11 (actual)
- First submitted
- 18 Apr 2024
- Start date
- 1 Sept 2023
- Primary completion date
- 31 Aug 2025
- Lead sponsor
- Universidade do Porto
- Diseases
- Chronic lymphocytic leukaemia
- NCT number
- NCT06396611
What you commit to
- Study type: Interventional
- Participants enrolled: 11
- From 1 Sept 2023 to the primary completion date, 31 Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous CLL treatments
Other illness
- Indication of disease progression and for starting treatment within 6 months
- Inability to perform exercise (Heart disease, advanced stage respiratory, renal, hepatic, neurological, or osteoarticular disease)
Other
- Ongoing engagement in a regular exercise program
- Other primary tumour
- Unable to travel to FADEUP facilities or comply with other study requirements
Who the study is looking for
- Confirmed diagnosis of CLL as per the International Workshop on CLL Guidelines
- No history of previous treatment of CLL
- Able to walk on a treadmill or cycle ergometer
- Able to carry weights, or use weight machines
- Pass initial evaluations (CPET for cardiac health, Isokinetic for muscular health)
- Willing to adhere to the exercise program
- Signed informed consent
Age in the registry: 45 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculty of Sport of University of Porto Coordinator of this site? Confirm its status | Porto | Portugal | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.