NCT06400290Recruiting
Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina
Source: ClinicalTrials.gov · Last updated 28 Oct 2026
Brief summary (registry, in English)
ORBITA-MOON is a double-blinded, placebo-controlled experimental study that aims to understand how the different coronary artery stenoses contribute to overall clinical angina in patients with multi-vessel coronary artery disease. This study will investigate the symptoms conferred by each stenosis, induced by experimental ischaemia, for 50 patients with multi-vessel coronary artery disease.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 24 Apr 2024
- Start date
- 13 Jun 2024
- Primary completion date
- Jan 2027
- Lead sponsor
- Imperial College London
- Diseases
- Coronary artery disease
- NCT number
- NCT06400290
What you commit to
- Study type: Interventional
- Planned participants: 50
- From 13 Jun 2024 to the primary completion date, Jan 2027
- 8 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous coronary artery by-pass graft surgery (CABG)
- Contraindication to PCI or a drug-eluting stents
- Contraindication to antiplatelet therapy
Other illness
- Recent acute coronary syndrome
- Significant left main stem disease
- Moderate to severe valvular disease
- Moderate to severe left ventricular impairment
Other
- Chronic total occlusion in the target artery(s)
- Contraindication to adenosine
- Pregnant
- Inability to consent
Who the study is looking for
- Eligibility for PCI due to angina
- Anatomical evidence of significant multi-vessel coronary stenosis defined by either:
- ≥70% stenosis in two or more coronary arteries of ≥2.5mm visual diameter stenosis, on invasive coronary angiography (ICA)
- Severe stenosis in ≥2 coronary arteries of ≥ 2.5mm visual diameter stenosis, on CTCA
- Physiological evidence of ischaemia with a positive test corresponding to the coronary arteries to be stented, on at least one of the following:
- dobutamine stress echocardiogram
- cardiac MRI
- myocardial perfusion study
- CT-FFR
- invasive metrics of coronary physiology
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (8)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Essex Cardiothoracic Centre Coordinator of this site? Confirm its status | Basildon | United Kingdom | Recruiting |
| Royal Bournemouth Hospital Coordinator of this site? Confirm its status | Bournemouth | United Kingdom | Recruiting |
| Royal Sussex County Hospital Coordinator of this site? Confirm its status | Brighton | United Kingdom | Recruiting |
| Imperial College NHS Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Royal Free London NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| St Georges University Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Portsmouth Hospitals University NHS Trust Coordinator of this site? Confirm its status | Portsmouth | United Kingdom | Not yet recruiting |
| University Hospital Southampton Coordinator of this site? Confirm its status | Southampton | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.