NCT06401928Completed
Electrical Brain Stimulation for Treatment of Secondary Symptoms in Multiple Sclerosis
Electrical Brain Stimulation for Improving Mental Health and Cognitive Functioning in Patients With Multiple Sclerosis
Source: ClinicalTrials.gov · Last updated 5 Aug 2026
Brief summary (registry, in English)
Multiple Sclerosis (MS) is an autoimmune disease associated with physical disability, psychological impairment, and cognitive dysfunction. As a result, the disease burden is high, and treatment options are limited. In this randomized, double-blind study, the investigators planned to use repeated electrical stimulation and assess mental health-related variables (e.g., quality of life, sleep, psychological distress) and cognitive dysfunction in patients with MS.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 53 (actual)
- First submitted
- 1 May 2024
- Start date
- 28 Feb 2023
- Primary completion date
- 15 Dec 2023
- Lead sponsor
- The National Brain Mapping Laboratory (NBML)
- Diseases
- Multiple sclerosis
- NCT number
- NCT06401928
What you commit to
- Study type: Interventional
- Participants enrolled: 53
- From 28 Feb 2023 to the primary completion date, 15 Dec 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- presence of ferromagnetic objects in the body that are contraindicated for brain stimulation of the head (pacemakers or other implanted electrical devices, brain stimulators, some types of dental implants, aneurysm clips, metallic prostheses, permanent eyeliner, implanted delivery pump, or shrapnel fragments) or fear of enclosed spaces.
Other illness
- history of seizure
- history of other neurological disorders than MS
- history of head injury
Other
- smoker
- pregnancy
- alcohol or substance dependence
Who the study is looking for
- diagnosis of MS according to the diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria (Polman et al., 2011), certified by a professional neurologist
- being 25-55 years old
- providing written informed consent
- If female, a negative urine pregnancy test
- stable medication regime especially the classical neuroleptics and all CNS-activating medications, if taken, 4-6 weeks before the experiment and during the experiment
- right handed
Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Multiple Sclerosis Association of Guilan Coordinator of this site? Confirm its status | Rasht | Iran | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.