NCT06404268RecruitingPhase 1/2
Facilitating Neuroplastic Changes of Acute Stroke Survivors
Facilitating Neuroplastic Changes of Acute Stroke Survivors With Severe Hemiplegia
Source: ClinicalTrials.gov · Last updated 23 Jul 2026
Brief summary (registry, in English)
This project will develop a wearable rehabilitation robot suitable for in-bed acute stage rehabilitation. It involves robot-guided motor relearning, passive and active motor-sensory rehabilitation early in the acute stage post-stroke including patients who are paralyzed with no motor output. The early acute stroke rehabilitation device will be evaluated in this clinical trial.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 68 (estimated)
- First submitted
- 1 May 2024
- Start date
- 1 Jun 2025
- Primary completion date
- 31 Aug 2028
- Lead sponsor
- University of Maryland, Baltimore
- Diseases
- Stroke
- NCT number
- NCT06404268
What you commit to
- Study type: Interventional · Phase 1/2
- Planned participants: 68
- From 1 Jun 2025 to the primary completion date, 31 Aug 2028
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Associated acute medical illness that interferes with ability to training and exercise
- No impairment or very mild ankle impairment of ankle
- Cognitive impairment or aphasia with inability to follow instructions
- Pressure ulcer, recent surgical incision or active skin disease with open wounds present below knee
Other
- Medically not stable
- Severe cardiovascular problems that interfere with ability to perform moderate movement exercises
- Severe pain in legs
- Severe ankle contracture greater than 15° plantar flexion (when pushing ankle to dorsiflexion)
Who the study is looking for
- Acute first time unilateral hemispheric stroke (hemorrhagic or ischemic stroke, 24 hours after admission to 1 month post-stroke at the start of the proposed treatment)
- Hemiplegia or hemiparesis
- 0≤Manual Muscle Testing (MMT)\<=2
- Age 30-85
- Ankle impairments including stiff calf muscles and/or inadequate dorsiflexion
Age in the registry: 30 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Maryland, Baltimore Coordinator of this site? Confirm its status | Baltimore | United States | Recruiting |
| UMROI Coordinator of this site? Confirm its status | Baltimore | United States | Recruiting |
| TIRR Memorial Hermann Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.