NCT06404554Completed
A Prediction Model of Anastomotic Stricture After Rectal Cancer
A Prediction Model of Anastomotic Stricture After Rectal Cancer: a Retrospective Cohort Analysis
Source: ClinicalTrials.gov · Last updated 8 May 2024
Brief summary (registry, in English)
Background: Anastomotic stricture significantly impacts patients' quality of life and long-term prognosis. However, current clinical practice lacks accurate tools for predicting anastomotic stricture. This study aimed to develop a nomogram to predict anastomotic stricture in patients with rectal cancer who have undergone anterior resection. Methods: 1542 eligible patients will be recruited for the study. Least absolute shrinkage selection operator (Lasso) analysis will be used to preliminarily select predictors. A prediction model will be constructed using multivariate logistic regression and presented as a nomogram. The performance of the nomogram will be evaluated using receiver operating characteristic (ROC) curves, calibration diagrams, and decision curve analysis (DCA). Internal validation will be conducted by assessing the model's performance on a validation cohort.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 1542 (actual)
- First submitted
- 5 May 2024
- Start date
- 1 Jan 2024
- Primary completion date
- 31 Mar 2024
- Lead sponsor
- Northern Jiangsu People's Hospital
- Diseases
- Colorectal cancer
- NCT number
- NCT06404554
What you commit to
- Study type: Observational
- Participants enrolled: 1542
- From 1 Jan 2024 to the primary completion date, 31 Mar 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- intraoperative discovery of widespread implant metastases within the abdominal cavity;
Other illness
- emergency surgery candidates due to conditions like perforation or obstruction;
- diagnosis of multiple primary malignancies;
- anastomotic recurrence of rectal cancer;
Other
- absence of postoperative follow-up or anastomosis details;
- patients subjected to Hartmann or Miles procedures;
- severe comorbidities;
- patients who had undergone stapled hemorrhoidopexy
Who the study is looking for
- pathological confirmation of rectal cancer;
- eligibility for surgical intervention;
- undergoing first rectal cancer surgery;
- acquisition of written informed consent from patients and their families;
- no history of hypertrophic scar or allergic predispositions.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Yifan Cheng Coordinator of this site? Confirm its status | Yangzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.