NCT06409637Not yet recruitingPhase 1/2
FOLFOX Plus Lenvatinib Adjuvant Therapy for Hepatocellular Carcinoma Post-Liver Transplantation
A Prospective, Single-arm Clinical Study of FOLFOX Combined With Lenvatinib as Adjuvant Chemotherapy to Prevent Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma Beyond Milan Criteria
Source: ClinicalTrials.gov · Last updated 10 May 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Liver transplantation not only removes the liver tumor (seed) but also eliminates the underlying diseased liver (soil), making it an essential therapeutic approach for hepatocellular carcinoma (HCC). However, the tumor recurrence post-liver transplantation significantly jeopardizing the long-term survival of transplant recipients. Given the scarcity of donor livers, exploring effective measures to prevent tumor recurrence after liver transplantation holds significant clinical and societal value. Currently, there is no consensus on adjuvant therapy for preventing tumor recurrence post-liver transplantation for HCC, and the quantity and quality of studies on systemic chemotherapy are limited. In recent years, administration of the FOLFOX regimen combined with lenvatinib has been widely used in the treatment of advanced HCC, showing remarkable efficacy. The aim of this study is to investigate the efficacy and safety of adjuvant chemotherapy with FOLFOX combined with lenvatinib in preventing tumor recurrence after liver transplantation for HCC beyond Milan criteria.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 62 (estimated)
- First submitted
- 7 May 2024
- Start date
- 1 Jan 2025
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT06409637
What you commit to
- Study type: Interventional · Phase 1/2
- Planned participants: 62
- From 1 Jan 2025 to the primary completion date, 31 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concurrent malignancies.
- Pregnant or lactating women (female participants must undergo pregnancy testing within 7 days prior to treatment).
- History of severe cardiovascular diseases: congestive heart failure \>NYHA class 2; active coronary artery disease (myocardial infarction within 6 months prior to enrollment); severe arrhythmias requiring antiarrhythmic therapy (β-blockers or digoxin permitted); uncontrolled hypertension.
- Patients unable to swallow oral medications, such as those with severe upper gastrointestinal obstruction requiring gastric tube feeding.
- Previous treatment with other anti-angiogenic therapies, surgery, TACE, local therapy, systemic chemotherapy, immunotherapy, etc., before liver transplantation.
Other illness
- Allergy to lenvatinib or chemotherapy drugs.
- History of HIV infection.
- Severe active clinical infections.
- Patients requiring medication for epilepsy (e.g., steroids or antiepileptic drugs).
- Patients with kidney diseases requiring dialysis.
- Drug abuse, medical conditions, psychiatric illnesses, or social status that may interfere with the participant's participation in the study or evaluation of study results.
Other
- Life expectancy less than 6 months.
- High suspicion of hepatocellular carcinoma recurrence and metastasis.
- Clear evidence of main portal vein/hepatic vein tumor thrombus or inferior vena cava tumor thrombus.
- Clear evidence of lymph node metastasis.
Who the study is looking for
- Age between 18 and 75 years inclusive.
- Histologically confirmed hepatocellular carcinoma without other non-hepatocellular carcinoma components.
- ECOG performance status 0-1.
- Child-Pugh class A liver function.
- Eligible for chemotherapy and targeted therapy within 1-2 months after liver transplantation.
- Immunosuppressive regimen including calcineurin inhibitors, mycophenolate mofetil, and sirolimus.
- Adequate liver, kidney, and bone marrow function: serum albumin \>28g/L, total bilirubin ≤3mg/dL (51.3 umol/l), ALT and AST ≤5 times the upper limit of normal; serum creatinine ≤1.5 times the upper limit of normal; hemoglobin \>90g/L, absolute neutrophil count (ANC) \>1.5×10\^9/L, platelet count \>60×10\^9/L; PT-INR \<1.5 or PT within normal limits +6 seconds.
- Negative serum/urine pregnancy test within 7 days prior to treatment initiation for fertile women.
- Reliable contraception must be used by all male and female participants during the trial and for six months after its completion.
- Ability to take oral medications.
- Participants must provide written informed consent.
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Organ Transplantation Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Coordinator of this site? Confirm its status | Guangzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.