NCT06410157Recruiting
Cardiac-Control Affecting Learning Through Mindfulness (CALM)
Source: ClinicalTrials.gov · Last updated 13 May 2026
Brief summary (registry, in English)
Some types of meditation lead heart rate to become more steady as breathing quiets whereas others lead to large heart rate swings up and down (oscillations) as breathing becomes deeper and slower. The current study is designed to investigate how daily mindfulness practice with heart rate biofeedback during breathing in a pattern that either increases or decreases heart rate oscillation affect attention and memory and blood biomarkers associated with Alzheimer's disease.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 240 (estimated)
- First submitted
- 6 May 2024
- Start date
- 14 Jan 2025
- Primary completion date
- Nov 2027
- Lead sponsor
- University of Southern California
- Diseases
- Alzheimer disease
- NCT number
- NCT06410157
What you commit to
- Study type: Interventional
- Planned participants: 240
- From 14 Jan 2025 to the primary completion date, Nov 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Have a disorder that would impede performing the breathing intervention (e.g., abnormal cardiac rhythm, arrhythmia, dyspnea)
- Have cognitive impairment
- Have any conditions listed below that are not safe for MRI
- \*Metal in any parts of your body
- Claustrophobia
- Have worked as a machinist, metal worker, or in any profession or hobby grinding metal?
- Have had an injury to the eye involving a metallic object (e.g., metallic slivers, shavings, or foreign body)
- Cardiac pacemaker
- Implanted cardiac defibrillator
- Aneurysm clip or brain clip
- Carotid artery vascular clamp
- Neurostimulator
- Insulin or infusion pump
- Spinal fusion stimulator
- Cochlear, otologic, ear tubes or ear implant
- Prosthesis (eye/orbital, penile, etc.)
- Implant held in place by a magnet
- Heart valve prosthesis
- Artificial limb or joint
- Other implants in body or head
- Electrodes (on body, head or brain)
- Intravascular stents, filters
- Shunt (spinal or intraventricular)
- Vascular access port or catheters
- IUD
- Transdermal delivery system or other types of foil patches (e.g., Nitro, Nicotine, Birth control, etc.) that cannot be removed for MRI
- Shrapnel, buckshot, or bullets
- Tattooed eyeliner or eyebrows
- Body piercing(s) that cannot be removed for MRI
- Metal fragments (eye, head, ear, skin)
- Internal pacing wires
- Aortic clips
- Metal or wire mesh implants
- Wire sutures or surgical staples
- Harrington rods (spine)
- Bone/joint pin, screw, nail, wire, plate
- Wig or toupee that cannot be removed for MRI
- Hair implants that involve staples or metal
- Hearing aid(s) that cannot be removed for MRI
- Dentures or retainers that cannot be removed for MRI
Other
- Have regularly played Lumosity games in the past 6 months
Who the study is looking for
- Fluent in English
- Black/African-American or White/European-American
- Aged between 50-70 years old
- Non-pregnant and non-menstruating (for at least the past year)
- Have normal or corrected-to-normal vision and hearing
- Have reliable access to wifi
- Have an email account that you check regularly
- Have a phone that receives text messages
- Agree to provide blood and urine samples at two campus visits
- Agree to devote up to 50 minutes daily to this study for 10 weeks as well as attend two campus visits
Age in the registry: 50 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Southern California Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.