NCT06415682Completed
The Efficacy and Mechanism of SMA+M1 Repetitive Transcranial Magnetic Stimulation on Freezing of Gait in PD
Source: ClinicalTrials.gov · Last updated 1 May 2025
Brief summary (registry, in English)
This study is a double-blinded randomized study examining the efficacy of the double-site (M1+SMA) repetitive transcranial magnetic stimulation on Freezing of Gait (FOG) in patients with Parkinson's disease. The investigators hypothesize that treatment using magnetic stimulation on double site (including M1-LL and SMA) will improve FOG and gait symptoms in patients with Parkinson's disease.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 64 (actual)
- First submitted
- 5 May 2024
- Start date
- 8 Oct 2024
- Primary completion date
- 21 Mar 2025
- Lead sponsor
- The First Affiliated Hospital with Nanjing Medical University
- Diseases
- Parkinson disease
- NCT number
- NCT06415682
What you commit to
- Study type: Interventional
- Participants enrolled: 64
- From 8 Oct 2024 to the primary completion date, 21 Mar 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- previously receiving any kinds of TMS interventions;
Other illness
- comorbidities of major neurologic diseases other than PD;
- suffer from musculoskeletal disorders that could have interfered with their ability to walk;
- severe cognitive impairment making cooperation impossible \[Mini Mental State Examination (MMSE) \< 24\];
Other
- presence of contraindications for transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI);
- marked tremor interfered with TMS detection;
- were unable to walk independently during the OFF state.
Who the study is looking for
- aged between 40-80 years;
- diagnosis of idiopathic Parkinson's disease (PD) according to the Movement Disorder Society clinical diagnostic criteria;
- patients were stable on dopaminergic treatment for at least 3 months;
- Item 3 of the Freezing of Gait Questionnaire(FOG-Q) scored ≥1;
- Patients experienced FOG during an interview.
Age in the registry: 40 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First Affiliated Hospital of Nanjing Medical University Coordinator of this site? Confirm its status | Nanjing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.