NCT06415864Completed
Oral Cladribine B-cell Study
Source: ClinicalTrials.gov · Last updated 30 Oct 2026
Brief summary (registry, in English)
To study the impact of cladribine on peripheral and intrathecal B-cell, plasma cells, T cells and Tregs
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 10 (actual)
- First submitted
- 3 Apr 2024
- Start date
- 1 Jul 2019
- Primary completion date
- 31 Jan 2024
- Lead sponsor
- Queen Mary University of London
- Diseases
- Multiple sclerosis
- NCT number
- NCT06415864
What you commit to
- Study type: Observational
- Participants enrolled: 10
- From 1 Jul 2019 to the primary completion date, 31 Jan 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Unsuitable to have a lumbar puncture, for example spinal deformity, tethered cord syndrome or the use of aspirin or anticoagulants, and those unable to comply with study requirements, including frequency of visits and lumbar punctures.
Lab values
- Abnormal baseline investigations (WBC\<3 x 10\*9/l, lymphocytes \<1.0 x 10\*9/l, neutrophil count \<1.5 x 10\*9/l, platelet count \<100 x 10\*9, haemoglobin \<110g/l, LFT\>/3x upper limit of normal of site reference ranges, potassium \<2.8mmol/l or \>5.5mmol/l, sodium \<125 mmol/l, creatinine \>130 umol/l)
Other
- Ineligible for oral cladribine under NHS England prescribing guidelines and those participating in MAGNIFY-MS study (cladribine tablets in active MS)
- Presence of comorbidities in which the administration of cladribine is contraindicated.
Who the study is looking for
- Patients with MS who are being treated with oral cladribine at Barts Health NHS Trust will be approached to participate in this study.
- Patients must be willing and able to undergo lumbar punctures
- Patients who are OCB positive in their CSF (previous diagnostic lumbar puncture)
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Barts Health NHS Trust Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.