NCT06416371Recruiting
Retinal Vessel Leakage in Cerebral Small Vessel Disease
Retinal Vessel Leakage in Cerebral Small Vessel Disease: a Sub-study of the Mild Stroke Study 3
Source: ClinicalTrials.gov · Last updated 4 Mar 2026
Brief summary (registry, in English)
The goal of this observational study is to learn about leakage from retinal vessels in cerebral small vessel disease. The main questions it aims to answer are: * Does retinal vessel leakage occur in cerebral small vessel disease? * If it does, is the severity of retinal vessel leakage similar to the severity of cerebral small vessel disease generally? Participants will be tested using fluorescein angiography. This involves an intravenous injection of fluorescent dye, and is a very sensitive way to find leakage from retinal blood vessels. Participants will have already had brain scans and other examinations and tests to measure the severity of their cerebral small vessel disease. Our new retinal images will complement the information from these previous tests.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 40 (estimated)
- First submitted
- 15 Jan 2024
- Start date
- 13 Jan 2025
- Primary completion date
- 15 Feb 2029
- Lead sponsor
- University of Edinburgh
- Diseases
- Stroke
- NCT number
- NCT06416371
What you commit to
- Study type: Observational
- Planned participants: 40
- From 13 Jan 2025 to the primary completion date, 15 Feb 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous treatment for retinal leakage (retinal laser, intravitreal anti-VEGF)
- Recent eye surgery
Other illness
- Pregnancy, renal failure
- Severe dementia
- Known allergy to fluorescein
- History of allergy such as food or drug induced urticaria or history of bronchial asthma
- Any other severe or acute medical or psychiatric conditions
Age
- Any condition known to cause retinal leakage (i.e., worse than background diabetic retinopathy, retinal vein occlusion, active uveitis, wet age-related macular degeneration, malignant hypertension)
Other
- Shallow anterior chambers as assessed by torch test
- Inability to give informed consent
Who the study is looking for
- Membership in the Mild Stroke Study 3 cohort
- Contrast enhanced MRI within 12 months
- Clear optical media in both eyes, as assessed by study investigator
- Best corrected visual acuity (near vision) ≥N36
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| NHS Lothian Coordinator of this site? Confirm its status | Edinburgh | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.