NCT06417411Active, not recruitingPhase 1/2
LEARNER- Low dosE AspiRiN prEterm tRial (Angola)
A Prospective, Randomized Controlled Study to Evaluate the Effects of Daily Low Dose Aspirin in Pregnant Women With Sickle Cell Disease When Initiated at the First Trimester Versus the Second Trimester of the Gestational Period
Source: ClinicalTrials.gov · Last updated 6 Jul 2026
Brief summary (registry, in English)
This study is being conducted to evaluate the safety and effect of starting daily use of low dose (100 mg) aspirin in pregnant women with sickle cell disease, who are being followed in two county hospitals in Angola, in the first trimester versus the second trimester of the gestational period.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 450 (estimated)
- First submitted
- 2 May 2024
- Start date
- 16 Mar 2024
- Primary completion date
- 30 Mar 2026
- Lead sponsor
- Instituto Nacional de Investigacao em Saude, Angola
- Diseases
- Sickle cell disease
- NCT number
- NCT06417411
What you commit to
- Study type: Interventional · Phase 1/2
- Planned participants: 450
- From 16 Mar 2024 to the primary completion date, 30 Mar 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- 1\. Pregnant women with Sickle Cell Disease in the third trimester (after week 27)
- 2\. HIV infection
- 3\. Diabetes mellitus
- 4\. Chronic hypertension
- 8\. Hypersensitivity to aspirin
- 9\. History of blood transfusion in the last 3 months
Lab values
- 5\. Liver disease measured by laboratory indication being 3 times above the upper limit of normal
Other
- 6\. Sickle nephropathy
- 7\. Multiple pregnancies
- 10.Those who did not consent to participate in the study.
Who the study is looking for
- 1\. Pregnant women with Sickle Cell Disease 15 years old and older
- 2\. Attending Maternidade Lucrecia Paim, Hospital Materno Infantil Dr. Manuel Pedro Azancot de Menezes, or any health commodities in the neighboring area of the referred hospitals
- 3\. Willing to attend the regular consultations, and consent to take part in the study.
Age in the registry: 15 years to - · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Instituto Nacional de Investigação Em Saúde Coordinator of this site? Confirm its status | Luanda | Angola | Unknown status |
Related publications
- LEARNER - A prospective, randomized controlled study to evaluate the effects of daily low dose aspirin in pregnant women with sickle cell disease when initiated at the first trimester versus the second trimester of the gestational period - study protocol.Contemp Clin Trials Commun · 2026 · PMID 42220645
This page is information, not medical advice. Discuss any trial with your doctor.